Bio-16-UTP
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Bio-16-UTP is a nucleotide analog that functions as a substrate for RNA polymerase in transcription reactions. It is incorporated into RNA molecules during transcription, leading to the synthesis of labeled RNA. This labeled RNA can then be used for various experimental purposes, such as studying gene expression, RNA localization, or RNA-protein interactions. Bio-16-UTP is designed to be recognized and utilized by RNA polymerase, allowing for the specific labeling of RNA transcripts. Its mechanism of action involves competing with UTP for incorporation into RNA, resulting in the production of labeled RNA molecules that can be detected and analyzed in experimental assays. Bio-16-Utp′s function as a substrate for RNA polymerase enables to study various aspects of RNA biology and gene expression without altering the transcription process.
Bio-16-UTP References
- Long Non-coding RNA TUG1 Sponges Mir-145a-5p to Regulate Microglial Polarization After Oxygen-Glucose Deprivation. | Wang, H., et al. 2019. Front Mol Neurosci. 12: 215. PMID: 31551710
- LncRNA CR749391 acts as a tumor suppressor to upregulate KLF6 expression via interacting with miR-181a in gastric cancer. | Shi, S., et al. 2020. Exp Ther Med. 19: 569-578. PMID: 31853323
- Rapid block of pre-mRNA splicing by chemical inhibition of analog-sensitive CRK9 in Trypanosoma brucei. | Gosavi, U., et al. 2020. Mol Microbiol. 113: 1225-1239. PMID: 32068297
- Functional analyses of mammalian virus 5'UTR-derived, small RNAs that regulate virus translation. | Li, ML. and Brewer, G. 2020. Methods. 183: 13-20. PMID: 32081746
- Mapping and Quantification of Non-Coding RNA Originating from the rDNA in Human Glioma Cells. | Sadova, AA., et al. 2020. Cancers (Basel). 12: PMID: 32731436
- lncRNA FGD5 antisense RNA 1 upregulates RORA to suppress hypoxic injury of human cardiomyocyte cells by inhibiting oxidative stress and apoptosis via miR‑195. | Cai, X., et al. 2020. Mol Med Rep. 22: 4579-4588. PMID: 33174051
- Novel small RNAs expressed by Bartonella bacilliformis under multiple conditions reveal potential mechanisms for persistence in the sand fly vector and human host. | Wachter, S., et al. 2020. PLoS Negl Trop Dis. 14: e0008671. PMID: 33216745
- The HIF-1α antisense long non-coding RNA drives a positive feedback loop of HIF-1α mediated transactivation and glycolysis. | Zheng, F., et al. 2021. Nat Commun. 12: 1341. PMID: 33637716
- A positive feedback regulatory loop involving the lncRNA PVT1 and HIF-1α in pancreatic cancer. | Zhu, Y., et al. 2021. J Mol Cell Biol. 13: 676-689. PMID: 34245303
- Macrophage polarization-associated lnc-Ma301 interacts with caprin-1 to inhibit hepatocellular carcinoma metastasis through the Akt/Erk1 pathway. | Luo, HL., et al. 2021. Cancer Cell Int. 21: 422. PMID: 34376192
- Hypoxia regulates overall mRNA homeostasis by inducing Met1-linked linear ubiquitination of AGO2 in cancer cells. | Zhang, H., et al. 2021. Nat Commun. 12: 5416. PMID: 34518544
- DDX3 modulates the tumor microenvironment via its role in endoplasmic reticulum-associated translation. | Chen, HH., et al. 2021. iScience. 24: 103086. PMID: 34568799
- The stalk domain of SARS-CoV-2 NSP13 is essential for its helicase activity. | Yue, K., et al. 2022. Biochem Biophys Res Commun. 601: 129-136. PMID: 35245742
- Cancer-associated fibroblast-specific lncRNA LINC01614 enhances glutamine uptake in lung adenocarcinoma. | Liu, T., et al. 2022. J Hematol Oncol. 15: 141. PMID: 36209111
- STRAIGHT-IN enables high-throughput targeting of large DNA payloads in human pluripotent stem cells. | Blanch-Asensio, A., et al. 2022. Cell Rep Methods. 2: 100300. PMID: 36313798
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Bio-16-UTP, 250 nmol | sc-500958 | 250 nmol | $408.00 |