Molecular structure of BINA, CAS Number: 866823-73-6
BINA (CAS 866823-73-6)
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Alternate Names:
Biphenyl-indanone A; 3′-[[(2-Cyclopentyl-2,3-dihydro-6,7-dimethyl-1-oxo-1H-inden-5-yl)oxy]methyl]-[1,1′-biph enyl]-4-carboxylic acid
Application:
BINA is a selective positive allosteric modulator of mGluR-2
CAS Number:
866823-73-6
Purity:
≥98%
Molecular Weight:
454.56
Molecular Formula:
C30H30O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
BINA is an organic compound characterized by its unique structure, comprising two aromatic rings connected by a single carbon atom. Extensive research has focused on exploring the potential applications of BINA. Notably, BINA exhibits remarkable inhibitory effects on the enzyme cyclooxygenase-2 (COX-2). Further, BINA is a selective positive allosteric modulator of mGluR-2. This compound displays no effect on glutamate-induced activation of other mGluR types. The exact mechanism of action for BINA remains not fully elucidated.
BINA (CAS 866823-73-6) References
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- A novel family of potent negative allosteric modulators of group II metabotropic glutamate receptors. | Hemstapat, K., et al. 2007. J Pharmacol Exp Ther. 322: 254-64. PMID: 17416742
- A selective positive allosteric modulator of metabotropic glutamate receptor subtype 2 blocks a hallucinogenic drug model of psychosis. | Benneyworth, MA., et al. 2007. Mol Pharmacol. 72: 477-84. PMID: 17526600
- Modulation of group II metabotropic glutamate receptor (mGlu2) elicits common changes in rat and mice sleep-wake architecture. | Ahnaou, A., et al. 2009. Eur J Pharmacol. 603: 62-72. PMID: 19046965
- Activation of mGlu2/3 metabotropic glutamate receptors negatively regulates the stimulation of inositol phospholipid hydrolysis mediated by 5-hydroxytryptamine2A serotonin receptors in the frontal cortex of living mice. | Molinaro, G., et al. 2009. Mol Pharmacol. 76: 379-87. PMID: 19439499
- Selective potentiation of the metabotropic glutamate receptor subtype 2 blocks phencyclidine-induced hyperlocomotion and brain activation. | Hackler, EA., et al. 2010. Neuroscience. 168: 209-18. PMID: 20350588
- Role of endocannabinoid and glutamatergic systems in DOI-induced head-twitch response in mice. | Egashira, N., et al. 2011. Pharmacol Biochem Behav. 99: 52-8. PMID: 21504759
- Functional and pharmacological characteristics of metabotropic glutamate receptors 2/4 heterodimers. | Kammermeier, PJ. 2012. Mol Pharmacol. 82: 438-47. PMID: 22653971
- Chronic treatment with LY341495 decreases 5-HT(2A) receptor binding and hallucinogenic effects of LSD in mice. | Moreno, JL., et al. 2013. Neurosci Lett. 536: 69-73. PMID: 23333599
- Stimulation of the metabotropic glutamate (mGlu) 2 receptor attenuates the MK-801-induced increase in the immobility time in the forced swimming test in rats. | Kawaura, K., et al. 2016. Pharmacol Rep. 68: 80-4. PMID: 26721357
- Molecular Switches of Allosteric Modulation of the Metabotropic Glutamate 2 Receptor. | Pérez-Benito, L., et al. 2017. Structure. 25: 1153-1162.e4. PMID: 28648611
- Effects of group II metabotropic glutamate receptor modulation on ethanol- and sucrose-seeking and consumption in the rat. | Windisch, KA. and Czachowski, CL. 2018. Alcohol. 66: 77-85. PMID: 29220747
- Selective Photoswitchable Allosteric Agonist of a G Protein-Coupled Receptor. | Donthamsetti, P., et al. 2021. J Am Chem Soc. 143: 8951-8956. PMID: 34115935
Activator of:
mGluR-2.Substrate of:
mGluR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BINA, 10 mg | sc-361121 | 10 mg | $134.00 | |||
BINA, 50 mg | sc-361121A | 50 mg | $756.00 |