Molecular structure of BIMU 8, CAS Number: 134296-40-5
BIMU 8 (CAS 134296-40-5)
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Application:
BIMU 8 is a potent full agonist of SR-4
CAS Number:
134296-40-5
Molecular Weight:
378.9
Molecular Formula:
C19H26N4O2•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
BIMU 8 is a potent SR-4 full agonist with a KD of 77 nM and EC50 = 18 nM for wild type SR-4. BIMU 8 binds to receptors in a mechanism different to that of the endogenous ligand 5-HT.
BIMU 8 (CAS 134296-40-5) References
- 5-HT4 receptor modulation of acetylcholine outflow in guinea pig brain slices. | Siniscalchi, A., et al. 1999. Neuroreport. 10: 547-51. PMID: 10208587
- Dual effects of 5-HT4 receptor activation on GABA release from guinea pig hippocampal slices. | Bianchi, C., et al. 2002. Neuroreport. 13: 2177-80. PMID: 12488792
- 5-hydroxytryptamine4 receptor agonists facilitate cholinergic transmission in the circular muscle of guinea pig ileum: antagonism by tropisetron and DAU 6285. | Tonini, M., et al. 1992. Life Sci. 50: PL173-8. PMID: 1315899
- Benzimidazolone derivatives: a new class of 5-hydroxytryptamine4 receptor agonists with prokinetic and acetylcholine releasing properties in the guinea pig ileum. | Rizzi, CA., et al. 1992. J Pharmacol Exp Ther. 261: 412-9. PMID: 1578356
- Benzimidazolone derivatives act as 5-HT4 receptor ligands in rat oesophagus. | Baxter, GS. and Clarke, DE. 1992. Eur J Pharmacol. 212: 225-9. PMID: 1601064
- Azabicycloalkyl benzimidazolone derivatives as a novel class of potent agonists at the 5-HT4 receptor positively coupled to adenylate cyclase in brain. | Dumuis, A., et al. 1991. Naunyn Schmiedebergs Arch Pharmacol. 343: 245-51. PMID: 1650917
- Investigation of cardiorespiratory effects of the selective 5-HT4 agonist BIMU-8 in etorphine-immobilised goats (Capra aegagrus hircus) in a randomized, blinded and controlled trial. | Tod, N., et al. 2021. Vet Rec. 189: e76. PMID: 33908044
- Benzimidazolones and renzapride facilitate acetylcholine release from guinea-pig myenteric plexus via 5-HT4 receptors. | Kilbinger, H., et al. 1995. Naunyn Schmiedebergs Arch Pharmacol. 351: 229-36. PMID: 7609775
- 5-HT4 receptor stimulation facilitates acetylcholine release in rat frontal cortex. | Consolo, S., et al. 1994. Neuroreport. 5: 1230-2. PMID: 7919171
- 5-HT1A and 5-HT4 receptors mediate inhibition and facilitation of fast synaptic transmission in enteric neurons. | Pan, H. and Galligan, JJ. 1994. Am J Physiol. 266: G230-8. PMID: 8141296
- Pharmacological characterization of the 5-hydroxytryptamine receptor coupled to adenylyl cyclase stimulation in human brain. | Monferini, E., et al. 1993. Life Sci. 52: PL61-5. PMID: 8437506
- Central cholinergic antinociception induced by 5HT4 agonists: BIMU 1 and BIMU 8. | Ghelardini, C., et al. 1996. Life Sci. 58: 2297-309. PMID: 8649219
- Neural 5-HT4 receptors in the human isolated detrusor muscle: effects of indole, benzimidazolone and substituted benzamide agonists and antagonists. | Candura, SM., et al. 1996. Br J Pharmacol. 118: 1965-70. PMID: 8864530
- Role of 5-HT4 receptors in the mouse passive avoidance test. | Galeotti, N., et al. 1998. J Pharmacol Exp Ther. 286: 1115-21. PMID: 9732367
Activator of:
SR-4.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BIMU 8, 5 mg | sc-362714 | 5 mg | $160.00 | |||
| US: Only available in the US | ||||||
BIMU 8, 10 mg | sc-362714A | 10 mg | $295.00 | |||
| US: Only available in the US | ||||||