Bimatoprost, free acid-d4 (CAS 58976-50-4)
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This compound contains four deuterium atoms at the 3, 3′, 4, and 4′ positions. It is intended for use as an internal standard for the quantification of bimatoprost (free acid) by GC- or LC-mass spectrometry. Bimatoprost (free acid) is a metabolically stable analog of prostaglandin F2α (PGF2α) and is a potent agonist for the FP receptor. It binds to the FP receptor on ovine luteal cells with a relative potency of 756% compared to that of PGF2α.1 At the rat recombinant FP receptor expressed in CHO cells bimatoprost (free acid) inhibits PGF2α binding with a Ki of 1.1 nM.2 The isopropyl ester of bimatoprost (free acid)-d4 is slightly better than PGF2α isopropyl ester in reducing the intraocular pressure in the cat eye without any irritation.3
Bimatoprost, free acid-d4 (CAS 58976-50-4) References
1 Balapure, A.K., Rexroad, C.E., Kawada, K., et al. Structural requirements for prostaglandin analog interaction with the ovine corpus luteum prostaglandin F2α receptor. Biochem Pharmacol 38 2375-2381 (1989). 2 Lake, S., Gullberg, H., Wahlqvist, J., et al. Cloning of the rat and human prostaglandin F2α receptors and the expression of the rat prostaglandin F2α receptor. FEBS Lett 355 317-325 (1994). 3 Stjernschantz, J., Resul, B. Phenyl substituted prostaglandin analogs for glaucoma treatment. Drugs of the Future 17 691-704 (1992).Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Bimatoprost, free acid-d4, 25 µg | sc-221362 | 25 µg | $101.00 | |||
Bimatoprost, free acid-d4, 50 µg | sc-221362A | 50 µg | $190.00 |