Molecular structure of Bimatoprost, free acid, CAS Number: 38344-08-0
Bimatoprost, free acid (CAS 38344-08-0)
Alternate Names:
17-Phenyl Trinor Prostaglandin F2-Alpha; 9α,11α,15S-trihydroxy-17-phenyl-18,19,20-trinor-prosta-5Z,13E-dien-1-oic acid; 17-phenyl trinor PGF2α
Application:
Bimatoprost, free acid is a metabolically stable analog of PGF2α
CAS Number:
38344-08-0
Purity:
>98%
Molecular Weight:
388.50
Molecular Formula:
C23H32O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Bimatoprost, free acid, a structural analog of prostaglandins, is a focal point in biochemical research, particularly for studying prostaglandin receptors and their role in biochemical signaling pathways. Utilized in non-clinical investigations, it aids in elucidating the activation and regulation mechanisms of these receptors. Beyond receptor studies, bimatoprost, free acid is also of interest in analytical chemistry, where it is used to refine methods for lipid analysis, due to its stability and distinctive chemical properties. In the field of biochemistry, it provides insights into the fundamental processes involving lipid compounds, without delving into its well-known clinical uses, thus broadening the understanding of lipid function and interaction in complex biological systems.
Bimatoprost, free acid (CAS 38344-08-0) References
- Real-time intracellular Ca2+ mobilization by travoprost acid, bimatoprost, unoprostone, and other analogs via endogenous mouse, rat, and cloned human FP prostaglandin receptors. | Kelly, CR., et al. 2003. J Pharmacol Exp Ther. 304: 238-45. PMID: 12490597
- The effects of prostaglandin analogues on IOP in prostanoid FP-receptor-deficient mice. | Ota, T., et al. 2005. Invest Ophthalmol Vis Sci. 46: 4159-63. PMID: 16249494
- Effect of bimatoprost on intraocular pressure in prostaglandin FP receptor knockout mice. | Crowston, JG., et al. 2005. Invest Ophthalmol Vis Sci. 46: 4571-7. PMID: 16303950
- Characterization of an in vivo model for the study of eyelash biology and trichomegaly: mouse eyelash morphology, development, growth cycle, and anagen prolongation by bimatoprost. | Tauchi, M., et al. 2010. Br J Dermatol. 162: 1186-97. PMID: 20346040
- The biodisposition and hypertrichotic effects of bimatoprost in mouse skin. | Woodward, DF., et al. 2013. Exp Dermatol. 22: 145-8. PMID: 23278986
- Bimatoprost protects retinal neuronal damage via Akt pathway. | Takano, N., et al. 2013. Eur J Pharmacol. 702: 56-61. PMID: 23395963
- Anandamide-derived prostamide F2α negatively regulates adipogenesis. | Silvestri, C., et al. 2013. J Biol Chem. 288: 23307-21. PMID: 23801328
- Activation of the prostanoid FP receptor inhibits adipogenesis leading to deepening of the upper eyelid sulcus in prostaglandin-associated periorbitopathy. | Taketani, Y., et al. 2014. Invest Ophthalmol Vis Sci. 55: 1269-76. PMID: 24508785
- In Vivo Effects of Preservative-free and Preserved Prostaglandin Analogs: Mouse Ocular Surface Study. | Kim, JH., et al. 2015. Korean J Ophthalmol. 29: 270-9. PMID: 26240512
- Structural requirements for prostaglandin analog interaction with the ovine corpus luteum prostaglandin F2 alpha receptor. Implications for development of a photoaffinity probe. | Balapure, AK., et al. 1989. Biochem Pharmacol. 38: 2375-81. PMID: 2751699
- The Effect of Prostaglandin Analogue Bimatoprost on Thyroid-Associated Orbitopathy. | Choi, CJ., et al. 2018. Invest Ophthalmol Vis Sci. 59: 5912-5923. PMID: 30551199
- Prostaglandin F2α agonist-induced suppression of 3T3-L1 cell adipogenesis affects spatial formation of extra-cellular matrix. | Ida, Y., et al. 2020. Sci Rep. 10: 7958. PMID: 32409724
- Addition of EP2 agonists to an FP agonist additively and synergistically modulates adipogenesis and the physical properties of 3D 3T3-L1 sphenoids. | Ida, Y., et al. 2021. Prostaglandins Leukot Essent Fatty Acids. 171: 102315. PMID: 34246925
- Prostaglandin analog effects on cerebrospinal fluid reabsorption via nasal mucosa. | Pedler, MG., et al. 2021. PLoS One. 16: e0248545. PMID: 34971554
- Cloning of the rat and human prostaglandin F2 alpha receptors and the expression of the rat prostaglandin F2 alpha receptor. | Lake, S., et al. 1994. FEBS Lett. 355: 317-25. PMID: 7988697
Activator of:
PGF2alphaR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Bimatoprost, free acid, 1 mg | sc-223818 | 1 mg | $101.00 | |||
Bimatoprost, free acid, 5 mg | sc-223818A | 5 mg | $437.00 | |||
Bimatoprost, free acid, 10 mg | sc-223818B | 10 mg | $629.00 |