Bilobalide (CAS 33570-04-6)
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Bilobalide is a terpenoid constituent found in Ginkgo biloba leaves, renowned for its unique structural framework and significant role in research focused on cognitive mechanisms. Unlike typical terpenoids, bilobalide exhibits a rare trilactone structure that contributes to its distinctive biological activities. In scientific investigations, it has been observed to modulate several pathways for neuronal research, including the expression of neurotrophic factors, inhibiting apoptotic pathways in neural cells, and scavenging free radicals. Furthermore, bilobalide′s ability to modulate gamma-aminobutyric acid (GABA) receptors highlights its potential in researching the complex mechanisms underlying neurotransmission and synaptic plasticity. By elucidating the molecular underpinnings of bilobalide′s actions, research aims to uncover new insights into the preservation of cognitive functions and the mechanisms through which neural cells resist degenerative processes.
Bilobalide (CAS 33570-04-6) References
- Bilobalide in Ginkgo biloba extract is a major substance inducing hepatic CYPs. | Umegaki, K., et al. 2007. J Pharm Pharmacol. 59: 871-7. PMID: 17637180
- Bilobalide modulates serotonin-controlled behaviors in the nematode Caenorhabditis elegans. | Brown, MK. and Luo, Y. 2009. BMC Neurosci. 10: 62. PMID: 19545409
- Bilobalide prevents apoptosis through activation of the PI3K/Akt pathway in SH-SY5Y cells. | Shi, C., et al. 2010. Apoptosis. 15: 715-27. PMID: 20333467
- Ginkgolides and bilobalide protect BV2 microglia cells against OGD/reoxygenation injury by inhibiting TLR2/4 signaling pathways. | Zhou, JM., et al. 2016. Cell Stress Chaperones. 21: 1037-1053. PMID: 27562518
- Bilobalide Suppresses Adipogenesis in 3T3-L1 Adipocytes via the AMPK Signaling Pathway. | Bu, S., et al. 2019. Molecules. 24: PMID: 31569605
- Sesquiterpenoid bilobalide inhibits gastric carcinoma cell growth and induces apoptosis both in vitro and in vivo models. | Liu, J., et al. 2021. J Biochem Mol Toxicol. 35: e22723. PMID: 33511709
- Bilobalide: A review of its pharmacology, pharmacokinetics, toxicity, and safety. | Lu, J., et al. 2021. Phytother Res. 35: 6114-6130. PMID: 34342079
- Bilobalide inhibits inflammation and promotes the expression of Aβ degrading enzymes in astrocytes to rescue neuronal deficiency in AD models. | Xiang, J., et al. 2021. Transl Psychiatry. 11: 542. PMID: 34671017
- Bilobalide Exerts Anti-Inflammatory Effects on Chondrocytes Through the AMPK/SIRT1/mTOR Pathway to Attenuate ACLT-Induced Post-Traumatic Osteoarthritis in Rats. | Ma, T., et al. 2022. Front Pharmacol. 13: 783506. PMID: 35281931
- Protective Effects of the Bilobalide on Retinal Oxidative Stress and Inflammation in Streptozotocin-Induced Diabetic Rats. | Su, Q., et al. 2022. Appl Biochem Biotechnol. 194: 6407-6422. PMID: 35932369
- Natural product, bilobalide, improves joint health in rabbits with osteoarthritis by anti-matrix degradation and antioxidant activities. | Ma, T., et al. 2022. Front Vet Sci. 9: 1034623. PMID: 36337189
- Protection of hypoxia-induced ATP decrease in endothelial cells by ginkgo biloba extract and bilobalide. | Janssens, D., et al. 1995. Biochem Pharmacol. 50: 991-9. PMID: 7575684
- Activity of bilobalide, a sesquiterpene from Ginkgo biloba, on Pneumocystis carinii. | Atzori, C., et al. 1993. Antimicrob Agents Chemother. 37: 1492-6. PMID: 8363381
- Regeneration of motor nerves in bilobalide-treated rats. | Bruno, C., et al. 1993. Planta Med. 59: 302-7. PMID: 8372143
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Bilobalide, 10 mg | sc-201061 | 10 mg | $80.00 | |||
Bilobalide, 25 mg | sc-201061B | 25 mg | $160.00 | |||
Bilobalide, 50 mg | sc-201061A | 50 mg | $290.00 | |||
Bilobalide, 100 mg | sc-201061C | 100 mg | $435.00 |