Molecular structure of Biliverdin hydrochloride, CAS Number: 55482-27-4
Biliverdin hydrochloride (CAS 55482-27-4)
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Alternate Names:
Biliverdin hydrochloride is known as a bile pigment.
Application:
Biliverdin hydrochloride is a heme oxygenase inhibitor and green bile pigment, able to be reduced to bilirubin.
CAS Number:
55482-27-4
Molecular Weight:
619.12
Molecular Formula:
C33H34N4O6•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Biliverdin hydrochloride is a bile pigment which is oxidized from bilirubin. It is known that there are α, β, γ, and δ isomers of Biliverdin hydrochloride. Studies suggest that Biliverdin hydrochloride can regulate the cellular heme degradation process by inhibiting substrates from binding to the the catalytic site of heme oxygenase. In addition, Biliverdin hydrochloride can be converted back into bilirubin by NAPDH/biliverdin reductase. Alternate studies show that methanol is an ideal solvent to use for spectroscopic determination of the non-α isomers of Biliverdin hydrochloride.
Biliverdin hydrochloride (CAS 55482-27-4) References
- The interplay between basicity, conformation, and enzymatic reduction in biliverdins. | Bari, S., et al. 1992. Biochem Biophys Res Commun. 188: 48-56. PMID: 1417867
- Synthesis, chromatographic purification, and analysis of isomers of biliverdin IX and bilirubin IX. | Heirwegh, KP., et al. 1991. Anal Biochem. 195: 273-8. PMID: 1750679
- Bilirubin as an antioxidant in micelles and lipid bilayers: its contribution to the total antioxidant capacity of human blood plasma. | MacLean, PD., et al. 2007. Free Radic Biol Med. 43: 600-9. PMID: 17640570
- Biliverdin production in chickens infected with the malarial parasite Plasmodium gallinaceum. | Williams, RB. 1985. Avian Pathol. 14: 409-19. PMID: 18766933
- A highly efficient pipeline for protein expression in Leishmania tarentolae using infrared fluorescence protein as marker. | Dortay, H. and Mueller-Roeber, B. 2010. Microb Cell Fact. 9: 29. PMID: 20459748
- The biliverdin-bilirubin antioxidant cycle of cellular protection: Missing a wheel? | McDonagh, AF. 2010. Free Radic Biol Med. 49: 814-20. PMID: 20547221
- Bile pigment pharmacokinetics and absorption in the rat: therapeutic potential for enteral administration. | Bulmer, AC., et al. 2011. Br J Pharmacol. 164: 1857-70. PMID: 21486273
- High-throughput protein expression using a combination of ligation-independent cloning (LIC) and infrared fluorescent protein (IFP) detection. | Dortay, H., et al. 2011. PLoS One. 6: e18900. PMID: 21541323
- Real-Time Protein-Fragment Complementation Assays for Studying Temporal, Spatial, and Spatiotemporal Dynamics of Protein-Protein Interactions in Living Cells. | Malleshaiah, M., et al. 2016. Cold Spring Harb Protoc. 2016: PMID: 27803255
- Identification of a biliverdin geometric isomer by means of HPLC/ESI-MS and NMR spectroscopy. Differentiation of the isomers by using fragmentation 'in-source'. | Frański, R., et al. 2018. Monatsh Chem. 149: 995-1002. PMID: 29887645
- Unprecedented Microbial Conversion of Biliverdin into Bilirubin-10-sulfonate. | Shiels, RG., et al. 2019. Sci Rep. 9: 2988. PMID: 30814600
- Integrated biomarker for type 2 diabetes mellitus and impaired fasting glucose based on metabolomics analysis using ultra-high performance liquid chromatography quadrupole-Orbitrap high-resolution accurate mass spectrometry. | Long, J., et al. 2020. Rapid Commun Mass Spectrom. 34: e8779. PMID: 32159245
- Stabilization of Near-Infrared Fluorescent Proteins by Packaging in Virus-like Particles. | Das, S., et al. 2020. Biomacromolecules. 21: 2432-2439. PMID: 32441521
Inhibitor of:
Heme Oxygenase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Biliverdin hydrochloride, 100 mg | sc-263030 | 100 mg | $240.00 | |||
Biliverdin hydrochloride, 250 mg | sc-263030A | 250 mg | $562.00 |