Bicyclomycin benzoate (CAS 37134-40-0)
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Bicyclomycin benzoate is a chemical compound used in research focused on bacterial RNA synthesis and protein translation mechanisms. It is particularly useful in the study of bacterial transcription termination, as it is known to inhibit RNA helicases, which are essential for certain stages of RNA processing. Researchers employ bicyclomycin benzoate to understand the role of these helicases in gene expression and to investigate the potential of targeting RNA helicase activity in bacteria. The benzoate salt form of bicyclomycin enhances its solubility, which is advantageous in various in vitro assay conditions. Furthermore, in biochemical studies, bicyclomycin benzoate is used to probe the interaction between small molecules and bacterial enzymes. It serves as a tool compound for dissecting the pathways and molecular interactions that are critical for bacterial viability.
Bicyclomycin benzoate (CAS 37134-40-0) References
- The ribB FMN riboswitch from Escherichia coli operates at the transcriptional and translational level and regulates riboflavin biosynthesis. | Pedrolli, D., et al. 2015. FEBS J. 282: 3230-42. PMID: 25661987
- Bicyclomycin Activity against Multidrug-Resistant Gram-Negative Pathogens. | Wang, W., et al. 2023. Microbiol Spectr. 11: e0379022. PMID: 36533939
- Extensive diversity in RNA termination and regulation revealed by transcriptome mapping for the Lyme pathogen B. burgdorferi. | Petroni, E., et al. 2023. bioRxiv.. PMID: 36712141
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Bicyclomycin benzoate, 5 mg | sc-362713 | 5 mg | $235.00 | |||
Bicyclomycin benzoate, 25 mg | sc-362713A | 25 mg | $650.00 |