Molecular structure of Bicyclol, CAS Number: 118159-48-1
Bicyclol (CAS 118159-48-1)
Application:
Bicyclol is The drug appears to protect against liver injury in animals.
CAS Number:
118159-48-1
Purity:
≥98%
Molecular Weight:
390.34
Molecular Formula:
C19H18O9
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
A anti-hepatitis drug, used in China for chronic hepatitis B and presumably C. The drug appears to protect against liver injury in animals. Recently was reported that bicyclol induces the expression of hepatic HSP27 and HSP70, and consequently inhibits the transcription factor NF-?B-mediated apoptosis and necrosis in liver tissue. It appears that bicyclol induces hepatic HSP27 and HSP70 expression through the activation transcription of HSPs genes.
Bicyclol (CAS 118159-48-1) References
Bao, X.Q., et al., Induction of heat shock protein 27 and 70 overexpression by bicyclol attenuates concanavalin A -induced liver injury through suppression of NF-{kappa}B in mice Mol. Pharmacol., (2009) Tan, W., et al., A study of intestinal absorption of bicyclol in rats: active efflux transport and metabolism as causes of its poor bioavailability J. Pharm. Pharm. Sci. 3rd ed., 11, 97-105, (2008) Zhao, J., et al., Protective effect of bicyclol on acute alcohol-induced liver injury in mice Eur. J. Pharmacol. 1-3th ed., 586, 322-331, (2008)Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Bicyclol, 5 mg | sc-252435 | 5 mg | $73.00 |