Bicyclo Prostaglandin E2 (CAS 74158-09-1)
QUICK LINKS
Bicyclo Prostaglandin E2 is a stable breakdown product of the PGE2 (sc-201225) metabolite 13,14-dihydro-15-keto Prostaglandin E2 (sc-205000). Assays designed to measure the biosynthesis and disposition of PGE2 measure the concentration of this bicyclic derivative due to its superior stability compared to PGE2 (half-life ~ 2 minutes) or 13,14-dihydro-15-keto Prostaglandin E2 (half-life ~ 9 minutes). Receptor binding studies indicate that although metabolites of prostaglandins typically bind to EP receptors with lower affinity, they might still play an important role in these biochemical pathways due to an increased half-life. It is difficult to distinguish effects brought on by parent compounds and metabolites for PGE2 systems due to the rapid and complex metabolism of this functionally complex molecule.
Bicyclo Prostaglandin E2 (CAS 74158-09-1) References
- Is hydrochlorothiazide-induced hypocalciuria due to inhibition of prostaglandin E2 synthesis? | Caló, L., et al. 1990. Clin Sci (Lond). 78: 321-5. PMID: 2156653
- Local benefit of prostaglandin E2 in radiochemotherapy-induced oral mucositis. | Matejka, M., et al. 1990. Br J Oral Maxillofac Surg. 28: 89-91. PMID: 2337569
- Serum metabonomics analysis of quercetin against the toxicity induced by cadmium in rats. | Jia, S., et al. 2020. J Biochem Mol Toxicol. 34: e22448. PMID: 31967702
- Metabolomic Changes in Naturally MAP-Infected Holstein-Friesian Heifers Indicate Immunologically Related Biochemical Reprogramming. | Taylor, EN., et al. 2021. Metabolites. 11: PMID: 34822384
- Bicyclo-prostaglandin E2 metabolite in congestive heart failure and relation to vasoconstrictor neurohumoral principles. | Punzengruber, C., et al. 1986. Am J Cardiol. 57: 619-23. PMID: 3513522
- On the metabolism of prostaglandins E 1 and E 2 in man. | Hamberg, M. and Samuelsson, B. 1971. J Biol Chem. 246: 6713-21. PMID: 5126221
- A radioimmunoassay for the unstable pulmonary metabolites of prostaglandin E1 and E2: an indirect index of their in vivo disposition and pharmacokinetics. | Bothwell, W., et al. 1982. J Pharmacol Exp Ther. 220: 229-35. PMID: 6948952
- Chemical instability of 15-keto-13,14-dihydro-PGE2: the reason for low assay reliability. | Granström, E., et al. 1980. Prostaglandins. 19: 933-57. PMID: 7384561
- Current approaches to estimation of eicosanoid formation in vivo. | Murphy, RC. and FitzGerald, GA. 1994. Adv Prostaglandin Thromboxane Leukot Res. 22: 341-8. PMID: 7771348
- In vivo formation of prostaglandin E1 and prostaglandin E2 in atopic dermatitis. | Leonhardt, A., et al. 1997. Br J Dermatol. 136: 337-40. PMID: 9115911
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Bicyclo Prostaglandin E2, 1 mg | sc-205222 | 1 mg | $71.00 | |||
Bicyclo Prostaglandin E2, 5 mg | sc-205222A | 5 mg | $323.00 |