(−)-Bicuculline methiodide (CAS 40709-69-1)
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(−)-Bicuculline methiodide is the N-methylated water-soluble derivative of the widely-employed ionotropic GABAA receptor antagonist Bicuculline (sc-202498). This quaternary amine derivative demonstrates similar GABAA receptor interaction as with the parent compound, though (−)-Bicuculline methiodide shows less specificity for this receptor and some activity at other sites. (−)-Bicuculline methiodide is observed to block afterhyperpolarizations mediated by Ca2+-activated K+ channels in dopaminergic neurons, an action unobserved with Bicuculline and other GABAA antagonists. This differential activity is most likely related to the quaternary nitrogen atom in (−)-Bicuculline methiodide. While still a useful tool for study alongside Bicuculline, this differential interaction is relevant and must be included in experiment design.
(−)-Bicuculline methiodide (CAS 40709-69-1) References
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- Blockade of GABA(A) receptors in the ventromedial hypothalamus further stimulates glucagon and sympathoadrenal but not the hypothalamo-pituitary-adrenal response to hypoglycemia. | Chan, O., et al. 2006. Diabetes. 55: 1080-7. PMID: 16567532
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(−)-Bicuculline methiodide, 50 mg | sc-200485 | 50 mg | $213.00 |