Molecular structure of Bicine, CAS Number: 150-25-4
Bicine (CAS 150-25-4)
See product citations (3)
Alternate Names:
Bicine is also known as Diethanolglycine.
Application:
Bicine is a zwitterionic amino acid buffer agent used for low temperature biochemical work in the 7.6 - 9.0 pH range.
CAS Number:
150-25-4
Purity:
≥99%
Molecular Weight:
163.17
Molecular Formula:
C6H13NO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Bicine is a zwitterionic amino acid buffer, active in the pH 7.6-9.0 range (pKa of 8.26 at 25°C). Bicine is a recommended buffer for low temperature biochemical work. Bicine is used for the preparation of stable substrate solution for serum guanase determination. The use of Bicine in a thin layer ion exchange chromatography method for protein resolution has been published. Bicine has been utilized in peptide and protein crystallization. A kinetic study of a quaternary transition-state analogue complex of creatine kinase used Bicine in the reaction buffer. A multiphasic buffer system for SDS-PAGE of proteins and peptides that incorporates Bicine has been described.
Bicine (CAS 150-25-4) References
- Conservation of phosphorylation state of cardiac phosphofructokinase during in vitro hypothermic hypoxia. | Pulis, RP., et al. 2000. Am J Physiol Heart Circ Physiol. 279: H2151-8. PMID: 11045948
- Determination of the affinity of each component of a composite quaternary transition-state analogue complex of creatine kinase. | Borders, CL., et al. 2002. Biochemistry. 41: 6995-7000. PMID: 12033932
- Ionic mobilities of duplex and frayed wire DNA in discontinuous buffer electrophoresis: evidence of interactions with amino acids. | Poon, GM., et al. 2004. Biochemistry. 43: 16337-47. PMID: 15610028
- Overexpression, crystallization and preliminary X-ray analysis of xylulose-5-phosphate/fructose-6-phosphate phosphoketolase from Bifidobacterium breve. | Suzuki, R., et al. 2010. Acta Crystallogr Sect F Struct Biol Cryst Commun. 66: 941-3. PMID: 20693675
- Synthesis, X-Ray Structure, and Characterization of Catena-bis(benzoate)bis{N,N-bis(2-hydroxyethyl)glycinate}cadmium(II). | Katsoulakou, E., et al. 2010. Bioinorg Chem Appl. 2010: 281932. PMID: 20976297
- Mn-bicine: a low affinity chelate for manganese ion enhanced MRI. | Seo, Y., et al. 2011. Magn Reson Med. 65: 1005-12. PMID: 21413064
- The synthesis and biological activity of lipophilic derivatives of bicine conjugated with N³-(4-methoxyfumaroyl)-L-2,3-diaminopropanoic acid (FMDP)-an inhibitor of glucosamine-6-phosphate synthase. | Koszel, D., et al. 2012. J Enzyme Inhib Med Chem. 27: 167-73. PMID: 21635214
- Changes to Extender, Cryoprotective Medium, and In Vitro Fertilization Improve Zebrafish Sperm Cryopreservation. | Matthews, JL., et al. 2018. Zebrafish. 15: 279-290. PMID: 29369744
- Characterization of Type IV Carboxylate Reductases (CARs) for Whole Cell-Mediated Preparation of 3-Hydroxytyrosol. | Horvat, M., et al. 2019. ChemCatChem. 11: 4171-4181. PMID: 31681448
- Bicine promotes rapid formation of β-sheet-rich amyloid-β fibrils. | Kim, HY., et al. 2020. PLoS One. 15: e0240608. PMID: 33048999
- Polyamines Counteract Carbonate-Driven Proteasome Stalling in Alkaline Conditions. | Kudriaeva, AA., et al. 2020. Biomolecules. 10: PMID: 33255475
- Influence of Zwitterionic Buffer Effects with Thermal Modification Treatments of Wood on Symbiotic Protists in Reticulitermes grassei Clément. | Duarte, S., et al. 2021. Insects. 12: PMID: 33562148
- Preformulation Studies with Phenylalanine Ammonia Lyase: Essential Prelude to a Microcapsule Formulation for the Management of Phenylketonuria. | Besada, C., et al. 2022. J Pharm Sci. 111: 1857-1867. PMID: 35351497
- Understanding the adsorption performance of two glycine derivatives as novel and environmentally safe anti-corrosion agents for copper in chloride solutions: experimental, DFT, and MC studies. | Elgendy, A., et al. 2019. RSC Adv. 9: 42120-42131. PMID: 35542890
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dUTPase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Bicine, 100 g | sc-216087 | 100 g | $112.00 | |||
Bicine, 250 g | sc-216087B | 250 g | $189.00 | |||
Bicine, 1 kg | sc-216087A | 1 kg | $292.00 |