Bicalutamide O-β-D-Glucuronide (CAS 151262-59-8)

Bicalutamide O-β-D-Glucuronide is a glucuronide conjugate of bicalutamide, primarily utilized in biochemical and environmental research to study the metabolism and excretion processes of xenobiotics in biological systems. This compound is specifically designed to mimic the metabolites formed during the glucuronidation phase of drug metabolism, a critical pathway where lipophilic substances are converted into water-soluble products for renal and biliary excretion. The attachment of the β-D-glucuronic acid to the bicalutamide molecule through an oxygen linkage significantly alters its physical and chemical properties, particularly its solubility and polarity. In research, Bicalutamide O-β-D-Glucuronide is used to investigate the efficiency and specificity of the enzymes involved in glucuronidation, primarily UDP-glucuronosyltransferases. This exploration helps in understanding how various substances are processed within the body and the factors influencing their biotransformation. Additionally, the study of such conjugates aids in the development of analytical methods to detect and quantify metabolites in biological samples, which is crucial for environmental monitoring and the assessment of xenobiotic exposure in wildlife and humans. Through these applications, Bicalutamide O-β-D-Glucuronide contributes to a broader comprehension of metabolic pathways and their implications in ecological and physiological contexts.