Molecular structure of BIBO 3304 trifluoroacetate, CAS Number: 191868-14-1
BIBO 3304 trifluoroacetate (CAS 191868-14-1)
See product citations (4)
Alternate Names:
N-[(1R)-1-[[[[4-[[(Aminocarbonyl)amino]methyl]phenyl]methyl]amino]carbonyl]-4-[(aminoiminomethyl)amino]butyl]-α-phenyl-benzeneacetamide ditrifluoroacetate
Application:
BIBO 3304 trifluoroacetate is a high affinity NPY1-R antagonist
CAS Number:
191868-14-1
Purity:
≥98%
Molecular Weight:
757.68
Molecular Formula:
C29H35N7O3•2CF3CO2H
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
Bibo 3304 trifluoroacetate has a role as a selective inhibitor of the enzyme protein arginine methyltransferase 5 (PRMT5). The compound has been examined for its impact on cellular regulation and survival, with findings indicating that it can influence cell growth and survival. Bibo 3304 trifluoroacetate functions by attaching to the catalytic section of PRMT5, leading to a decrease in symmetric dimethylarginine (sDMA), a post-translational modification PRMT5 catalyzes. This action disrupts normal gene expression patterns and impacts cell survival.
BIBO 3304 trifluoroacetate (CAS 191868-14-1) References
- Intrathecal neuropeptide Y inhibits behavioral and cardiovascular responses to noxious inflammatory stimuli in awake rats. | Mahinda, TB. and Taylor, BK. 2004. Physiol Behav. 80: 703-11. PMID: 14984805
- Intraamygdaloid administration of BIBO 3304 increases water intake and extends anxiolytic effects. | Wierońska, JM., et al. 2004. Pol J Pharmacol. 56: 867-70. PMID: 15662103
- Anxiolytic action of group II and III metabotropic glutamate receptors agonists involves neuropeptide Y in the amygdala. | Wierońska, JM., et al. 2005. Pharmacol Rep. 57: 734-43. PMID: 16382191
- The effect of intrahippocampal injection of group II and III metobotropic glutamate receptor agonists on anxiety; the role of neuropeptide Y. | Smiałowska, M., et al. 2007. Neuropsychopharmacology. 32: 1242-50. PMID: 17133262
- Oxidative stress attenuates NO-induced modulation of sympathetic neurotransmission in the mesenteric arterial bed of spontaneously hypertensive rats. | Macarthur, H., et al. 2008. Am J Physiol Heart Circ Physiol. 294: H183-9. PMID: 17965279
- The role of neuropeptide Y in the expression and extinction of fear-potentiated startle. | Gutman, AR., et al. 2008. J Neurosci. 28: 12682-90. PMID: 19036961
- A role for neuropeptide Y Y5 but not the Y1-receptor subtype in food deprivation-induced reinstatement of heroin seeking in the rat. | Maric, T., et al. 2011. Psychopharmacology (Berl). 218: 693-701. PMID: 21629996
- Infusions of neuropeptide Y into the lateral septum reduce anxiety-related behaviors in the rat. | Trent, NL. and Menard, JL. 2011. Pharmacol Biochem Behav. 99: 580-90. PMID: 21693128
- NPY/Y₁ receptor-mediated vasoconstrictory and proliferative effects in pulmonary hypertension. | Crnkovic, S., et al. 2014. Br J Pharmacol. 171: 3895-907. PMID: 24779394
- Insulin increases sympathetic nerve activity in part by suppression of tonic inhibitory neuropeptide Y inputs into the paraventricular nucleus in female rats. | Cassaglia, PA., et al. 2016. Am J Physiol Regul Integr Comp Physiol. 311: R97-R103. PMID: 27122366
- Kisspeptin Stimulates Growth Hormone Release by Utilizing Neuropeptide Y Pathways and Is Dependent on the Presence of Ghrelin in the Ewe. | Foradori, CD., et al. 2017. Endocrinology. 158: 3526-3539. PMID: 28977590
- Requirement for neuropeptide Y in the development of type 2 responses and allergen-induced airway hyperresponsiveness and inflammation. | Oda, N., et al. 2019. Am J Physiol Lung Cell Mol Physiol. 316: L407-L417. PMID: 30604629
- Intra-articular injection of 2-pyridylethylamine produces spinal NPY-mediated antinociception in the formalin-induced rat knee-joint pain model. | Souza-Silva, E., et al. 2020. Brain Res. 1735: 146757. PMID: 32135147
- Direct inhibition of arcuate kisspeptin neurones by neuropeptide Y in the male and female mouse. | Hessler, S., et al. 2020. J Neuroendocrinol. 32: e12849. PMID: 32337804
Inhibitor of:
NPY1-R.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BIBO 3304 trifluoroacetate, 10 mg | sc-203841 | 10 mg | $345.00 | |||
| US: Only available in the US | ||||||
BIBO 3304 trifluoroacetate, 50 mg | sc-203841A | 50 mg | $1437.00 | |||
| US: Only available in the US | ||||||