BIBO 3304 trifluoroacetate CAS: 191868-14-1
MF: C29H35N7O3•2CF3CO2H
MW: 757.68
A high affinity NPY1-R antagonist.

BIBO 3304 trifluoroacetate (CAS 191868-14-1)

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Alternate Names: N-[(1R)-1-[[[[4-[[(Aminocarbonyl)amino]methyl]phenyl]methyl]amino]carbonyl]-4-[(aminoiminomethyl)amino]butyl]-α-phenyl-benzeneacetamide ditrifluoroacetate
Application: BIBO 3304 trifluoroacetate is a high affinity NPY1-R antagonist
CAS Number: 191868-14-1
Purity: ≥98%
Molecular Weight: 757.68
Molecular Formula: C29H35N7O32CF3CO2H
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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BIBO 3304 trifluoroacetate is a high affinity NPY1-R antagonist (IC50 values are 0.38 and 0.72 nM at human and rat receptors respectively) that displays > 2600-fold selectivity over NPY2-R, NPY4-R and NPY5-R receptors. Inhibits NPY- and fasting-induced feeding in vivo following central administration. Also antagonizes anxiolytic-like effects of NPY (neuropeptide Y).


References

Wieland et al (1998) Subtype selectivity of the novel nonpeptide neuropeptide Y Y1 receptor antagonist BIBO 3304 and its effect on feeding in rodents. Br.J.Pharmacol. 125 549. Sajdyk et al (1999) Amygdalar neuropeptide Y Y1 receptors mediate the anxiolytic-like actions of neuropeptide Y in the social interaction test. Eur.J.Pharmacol. 368 143. Lecklin et al (2002) Receptor subtypes Y1 and Y5 mediate neuropeptide Y induced feeding in the guinea-pig. Br.J.Pharmacol. 135 2029.

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM), and ethanol (100 mM).
Storage :
Store at 4° C
Refractive Index :
n20D ~1.64 (Predicted)
Optical Activity :
α20/D -4.4°, c = 1 in DMSO
IC50 :
NPY1-R : IC50 = 0.38 nM (human); NPY Y1 receptor: IC50 = 0.72 nM (rat)
Ki Data :
NPY1-R: Ki= 0.25 nM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
CY1482730
SMILES :
NC(=N)NCCC[[email protected]@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(CNC(=O)N)cc1

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Certificate of Analysis

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BIBO 3304 trifluoroacetate (CAS 191868-14-1) Product Citations

See how others have used BIBO 3304 trifluoroacetate (CAS 191868-14-1). Click on the entry to view the PubMed entry .

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PMID: # 26131716  2015. PloS one. 10: e0131124.

Citations 1 to 1 of 1 total

can we give BIBO3340 through IV line, if yes, in which solution should it be dissolved in?

Asked by: amer
Our products are for in vitro laboratory research use only. Not for use in humans or animals in the diagnosis of disease or other conditions, or in the cure, mitigation, treatment, or prevention of disease.
Answered by: Technical Support
Date published: 2019-02-23
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