Molecular structure of BIBF1120, CAS Number: 656247-17-5
BIBF1120 (CAS 656247-17-5)
See product citations (2)
Alternate Names:
Vargatef; Nintedanib, Free Base
Application:
BIBF1120 is BIBF1120 is a potent kinase inhibitor found to affect VEGF, PDGF, and FGF receptors
CAS Number:
656247-17-5
Purity:
≥99%
Molecular Weight:
539.62
Molecular Formula:
C31H33N5O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
BIBF1120 inhibits PDGFR kinase activity of PDGFR-alpha and PDGFR-beta types with IC50 values of 59 and 65 nM, respectively. In addition, BIBF1120 suppresses the FGFR subtypes with IC50 of 60, 37 and 108 nM for Flg (FGFR1), Bek (FGFR2), and FGFR-3, respectively. BIBF1120 binds to the ATP-binding site in the cleft between the amino and carboxy terminal lobes of the kinase domain. BIBF1120 is an inhibitor of Flk-1, Flt-1 and Flt-4.
BIBF1120 (CAS 656247-17-5) References
- BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy. | Hilberg, F., et al. 2008. Cancer Res. 68: 4774-82. PMID: 18559524
- Effect of BIBF 1120 on reversal of ABCB1-mediated multidrug resistance. | Xiang, QF., et al. 2011. Cell Oncol (Dordr). 34: 33-44. PMID: 21290212
- BIBF 1120 (nintedanib), a triple angiokinase inhibitor, induces hypoxia but not EMT and blocks progression of preclinical models of lung and pancreatic cancer. | Kutluk Cenik, B., et al. 2013. Mol Cancer Ther. 12: 992-1001. PMID: 23729403
- BIBF 1120/ nintedanib : a new triple angiokinase inhibitor-directed therapy in patients with non-small cell lung cancer. | Rolfo, C., et al. 2013. Expert Opin Investig Drugs. 22: 1081-8. PMID: 23790097
- Serum amyloid A stimulates cultured endothelial cells to migrate and proliferate: inhibition by the multikinase inhibitor BIBF1120. | Cai, X., et al. 2013. Clin Exp Pharmacol Physiol. 40: 662-70. PMID: 23819722
- Functional relevance of a six mesenchymal gene signature in epithelial-mesenchymal transition (EMT) reversal by the triple angiokinase inhibitor, nintedanib (BIBF1120). | Huang, RY., et al. 2015. Oncotarget. 6: 22098-113. PMID: 26061747
- BIBF1120 (Vargatef) Inhibits Preretinal Neovascularization and Enhances Normal Vascularization in a Model of Vasoproliferative Retinopathy. | Rivera, JC., et al. 2015. Invest Ophthalmol Vis Sci. 56: 7897-907. PMID: 26670826
- Tyrosine kinase inhibitor BIBF1120 ameliorates inflammation, angiogenesis and fibrosis in CCl4-induced liver fibrogenesis mouse model. | Öztürk Akcora, B., et al. 2017. Sci Rep. 7: 44545. PMID: 28291245
- Harnessing affinity-based protein profiling to reveal a novel target of nintedanib. | Chen, X., et al. 2021. Chem Commun (Camb). 57: 3139-3142. PMID: 33634807
- Nintedanib and Dasatinib Treatments Induce Protective Autophagy as a Potential Resistance Mechanism in MPM Cells. | Hegedüs, L., et al. 2022. Front Cell Dev Biol. 10: 852812. PMID: 35392170
- PAX5 fusion genes are frequent in poor risk childhood acute lymphoblastic leukaemia and can be targeted with BIBF1120. | Fazio, G., et al. 2022. EBioMedicine. 83: 104224. PMID: 35985167
- Cancer-Associated Fibroblasts in Cholangiocarcinoma: Current Knowledge and Possible Implications for Therapy. | Montori, M., et al. 2022. J Clin Med. 11: PMID: 36362726
- BIBF1120 Protects against Diabetic Retinopathy through Neovascularization-Related Molecules and the MAPK Signaling Pathway. | Cao, X., et al. 2023. J Ophthalmol. 2023: 7355039. PMID: 37152616
Inhibitor of:
2900062L11Rik, 7420461P10Rik, A430084P05Rik, AFP, ALG11, Angptl1, ASPH, Bek, bFGF, CLEC-2B, CLEC-2E, COL1A1, COL3A1, COL5A3, DDR2, EG-VEGF, EGFL6, EGFL7, FAM75C2, FGF-BP3, FGFR-3, FIBP, Fibroblast Marker, Fibronectin, FIR, Flg, Flk-1, Flt-1, Flt-4, FRRS1, GFR-1, GFRA (GDNF family receptor alpha), Gm3336, H2-Kk, HEAB, HRG-β3, IGF2AS, Kar9, KIR2DS3, KRAP, Lefty, Lyn, MIG, Nanog, neuropilin, Olfr157, Olfr541, Olr1128, Olr1264, Olr1320, Olr1558, Olr272, Olr354, Olr37, Olr659, Olr72, Olr736, Olr750, Olr87, p-Tyr, PDGF-C, PDGF-D, PDGFR-alpha, PDGFR-beta, Pilr-β2, PL6, PODNL1, PRR9, rat endothelium, robo4, Rse, SEF14, SEMA3A, Sialyltransferase 7D, Siglec-H, Skint10, Srb4, TCR V3 γ, TGFα, Tie-1, Trav12d-1, TRBV3, Vasohibin-2, VG5Q, VHR, Vmn2r27, VSIG10, and ZNF883.Activator of:
β-FR, C20orf160, EphB2, FAPα, FBXO44, FGF-2, FREM2, Integrin α11, MAWDBP1, PlGF, PRAT4B_Cnpy4, RIOK1, sGC β1, sGC β2, SNRPC, TARSH, and Vasohibin-1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BIBF1120, 5 mg | sc-364433 | 5 mg | $180.00 | |||
BIBF1120, 10 mg | sc-364433A | 10 mg | $315.00 |