Molecular structure of BF 2649, CAS Number: 903576-44-3
BF 2649 (CAS 903576-44-3)
Alternate Names:
Ciproxidine; BF 2649 hydrochloride
Application:
BF 2649 is a histamine H3 receptor antagonist and inverse agonist
CAS Number:
903576-44-3
Molecular Weight:
332.31
Molecular Formula:
C17H26ClNO.HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
BF 2649 has been shown to be a histamine H3 receptor antagonist and inverse agonist.
BF 2649 (CAS 903576-44-3) References
- BF2.649 [1-{3-[3-(4-Chlorophenyl)propoxy]propyl}piperidine, hydrochloride], a nonimidazole inverse agonist/antagonist at the human histamine H3 receptor: Preclinical pharmacology. | Ligneau, X., et al. 2007. J Pharmacol Exp Ther. 320: 365-75. PMID: 17005916
- Brain histamine and schizophrenia: potential therapeutic applications of H3-receptor inverse agonists studied with BF2.649. | Ligneau, X., et al. 2007. Biochem Pharmacol. 73: 1215-24. PMID: 17343831
- Amine-constrained pyridazinone histamine H₃ receptor antagonists. | Sundar, BG., et al. 2011. Bioorg Med Chem Lett. 21: 5543-6. PMID: 21824776
- Novel morpholine ketone analogs as potent histamine H3 receptor inverse agonists with wake activity. | Sundar, BG., et al. 2012. Bioorg Med Chem Lett. 22: 1546-9. PMID: 22297111
- Commentary: Histaminergic Drugs Could be Novel Targets for Neuroprotection in CNS Disorders. | Sharma, HS., et al. 2016. CNS Neurol Disord Drug Targets. 15: 642-3. PMID: 27501948
- Histamine H3 Inverse Agonist BF 2649 or Antagonist with Partial H4 Agonist Activity Clobenpropit Reduces Amyloid Beta Peptide-Induced Brain Pathology in Alzheimer's Disease. | Patnaik, R., et al. 2018. Mol Neurobiol. 55: 312-321. PMID: 28861757
- Novel Treatment Strategies Using TiO2-Nanowired Delivery of Histaminergic Drugs and Antibodies to Tau With Cerebrolysin for Superior Neuroprotection in the Pathophysiology of Alzheimer's Disease. | Sharma, A., et al. 2017. Int Rev Neurobiol. 137: 123-165. PMID: 29132541
- Histamine H3 and H4 receptors modulate Parkinson's disease induced brain pathology. Neuroprotective effects of nanowired BF-2649 and clobenpropit with anti-histamine-antibody therapy. | Sharma, A., et al. 2021. Prog Brain Res. 266: 1-73. PMID: 34689857
- Nanodelivery of Histamine H3/H4 Receptor Modulators BF-2649 and Clobenpropit with Antibodies to Amyloid Beta Peptide in Combination with Alpha Synuclein Reduces Brain Pathology in Parkinson's Disease. | Buzoianu, AD., et al. 2023. Adv Neurobiol. 32: 55-96. PMID: 37480459
- Nanodelivery of histamine H3 receptor inverse agonist BF-2649 with H3 receptor antagonist and H4 receptor agonist clobenpropit induced neuroprotection is potentiated by antioxidant compound H-290/51 in spinal cord injury. | Buzoianu, AD., et al. 2023. Int Rev Neurobiol. 172: 37-77. PMID: 37833018
Inhibitor of:
Histamine H3 Receptor.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BF 2649, 10 mg | sc-361119 | 10 mg | $170.00 | |||
| US: Only available in the US | ||||||
BF 2649, 50 mg | sc-361119A | 50 mg | $726.00 | |||
| US: Only available in the US | ||||||
BF 2649, 100 mg | sc-361119B | 100 mg | $1000.00 | |||
| US: Only available in the US | ||||||
BF 2649, 1 g | sc-361119C | 1 g | $3600.00 | |||
| US: Only available in the US | ||||||