Molecular structure of Bexarotene, CAS Number: 153559-49-0
Bexarotene (CAS 153559-49-0)
See product citations (6)
Alternate Names:
4-[1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl)benzoic Acid; LG 100069; LG 1069; LG 69; LGD 1069; RO 26-4455; SR 11247; Targret; Targretin; Targretyn; Targrexin
Application:
Bexarotene is a selective agonist of retinoid X receptors
CAS Number:
153559-49-0
Purity:
≥98%
Molecular Weight:
348.48
Molecular Formula:
C24H28O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Bexarotene is a retinoid that functions as a selective agonist for retinoid X receptors (RXRs). It acts by binding to and activating RXRs, which in turn form heterodimers with other nuclear receptors to regulate gene expression. Bexarotene may activate RXR subtypes, leading to the modulation of gene transcription involved in cellular differentiation, proliferation, and apoptosis. Bexarotene′s mechanism of action involves its ability to bind to RXRs and influence the expression of genes related to cell growth and differentiation. By targeting RXRs, bexarotene plays a role in regulating cellular processes at the molecular level, making it useful for investigating the mechanisms of gene regulation and cellular signaling pathways in experimental applications.
Bexarotene (CAS 153559-49-0) References
- Oral bexarotene in the treatment of cutaneous T-cell lymphoma. | Wong, SF. 2001. Ann Pharmacother. 35: 1056-65. PMID: 11573857
- Bexarotene and DAB(389)IL-2 (denileukin diftitox, ONTAK) in treatment of cutaneous T-cell lymphomas: algorithms. | Duvic, M. 2000. Clin Lymphoma. 1 Suppl 1: S51-5. PMID: 11707865
- Bexarotene gel: a new skin-directed treatment option for cutaneous T-cell lymphomas. | Martin, AG. 2003. J Drugs Dermatol. 2: 155-67. PMID: 12852367
- The optimal use of bexarotene in cutaneous T-cell lymphoma. | Gniadecki, R., et al. 2007. Br J Dermatol. 157: 433-40. PMID: 17553039
- Bexarotene protects against neurotoxicity partially through a PPARγ-dependent mechanism in mice following traumatic brain injury. | He, J., et al. 2018. Neurobiol Dis. 117: 114-124. PMID: 29886067
- Bexarotene - a novel modulator of AURKA and the primary cilium in VHL-deficient cells. | Chowdhury, P., et al. 2018. J Cell Sci. 131: PMID: 30518623
- Bexarotene Attenuates Focal Cerebral Ischemia-Reperfusion Injury via the Suppression of JNK/Caspase-3 Signaling Pathway. | Liu, H., et al. 2019. Neurochem Res. 44: 2809-2820. PMID: 31680194
- Bexarotene Enhances Macrophage Erythrophagocytosis and Hematoma Clearance in Experimental Intracerebral Hemorrhage. | Chang, CF., et al. 2020. Stroke. 51: 612-618. PMID: 31826730
- Bexarotene Improve Depression-Like Behaviour in Mice by Protecting Against Neuro-inflammation and Synaptic Damage. | Yuan, C., et al. 2020. Neurochem Res. 45: 1500-1509. PMID: 32170675
- Bexarotene inhibits cell proliferation by inducing oxidative stress, DNA damage and apoptosis via PPARγ/ NF-κB signaling pathway in C6 glioma cells. | Hacioglu, C., et al. 2021. Med Oncol. 38: 31. PMID: 33599853
- Bexarotene-induced cell death in ovarian cancer cells through Caspase-4-gasdermin E mediated pyroptosis. | Kobayashi, T., et al. 2022. Sci Rep. 12: 11123. PMID: 35778597
- Inhibition of Integrin αVβ3 Signaling Improves the Antineoplastic Effect of Bexarotene in Cutaneous T-Cell Lymphoma. | Cayrol, F., et al. 2022. Mol Cancer Ther. 21: 1485-1496. PMID: 35793463
- Bexarotene enhances astrocyte phagocytosis via ABCA1-mediated pathways in a mouse model of subarachnoid hemorrhage. | Chen, P., et al. 2022. Exp Neurol. 358: 114228. PMID: 36108713
Inhibitor of:
1300002K09Rik, ABCG1, APP, c-Erb-A α-2, c-Erb-A β-2, C1orf31, C2orf89, C4a, CRBP I, Cytokeratin 5, Cytokeratin 6B, Cytokeratin 6C, DHRS3, EG546488, Esp3, FOXE2, GPR17, GREB1L, HoxB1, Ichthyin, Keratin 75, KRTAP10-2, KRTAP2-3, KRTAP20-1, KRTAP27-1, KRTAP5-1, KRTAP9-2, LCE2D, LRAT, LXRα, melanopsin, Mrf-2, N-CoR, PRAMEF20, RAI2, RAI3, RAMP1, RAR gamma, RARα1, Rarres1, RBP2, RXRβ, RXRβ1, TMEM25, TRα, and TR2.Activator of:
apoA, B42, c-Erb-A α-2, c-Erb-A β-1, CRABP-I, CRABP-II, CRBP III, CRBP IV, CYP26, CYP26B1, CYP26C1, DHRS7C, DHRS9, IFT172, KLK13, Lce1i, LXR beta, NP60, PAPP-A, Peripherin, PHYHIP, PRAMEF20, RAR beta, RARα1, RARα2, Rarres1, RDH8, Retinal RX, Retinal RX2, RORβ, RORγ, RXR alpha, RXR beta, RXR gamma, RXRβ1, RXRβ2, Sprr2h, Sprr2i, Stra6, TARDBP, TIG1, TIG3, TRβ2, and Triiodothyronine.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Bexarotene, 10 mg | sc-217753 | 10 mg | $55.00 | |||
Bexarotene, 100 mg | sc-217753A | 100 mg | $250.00 |