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Betamethasone 21-acetate (CAS 987-24-6)

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Alternate Names:
9α-Fluoro-16β-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione 21-acetate
CAS Number:
987-24-6
Molecular Weight:
434.50
Molecular Formula:
C24H31FO6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Betamethasone 21-acetate also know as Betamethasone acetate is an acetate ester, a steroid ester, a fluorinated steroid, a 17alpha-hydroxy steroid, a 20-oxo steroid, an 11beta-hydroxy steroid, and a tertiary alpha-hydroxy ketone. It is a structural analog of betamethasone. In the context of biochemical mechanisms, betamethasone and its derivatives like betamethasone 21-acetate interact with glucocorticoid receptors. These receptors are part of the nuclear receptor family, which, upon activation, translocate to the nucleus and influence the transcription of various genes. The genes affected by glucocorticoid receptor activation are involved in regulating inflammatory responses.


Betamethasone 21-acetate (CAS 987-24-6) References

  1. Characterization of inclusion complexes of betamethasone-related steroids with cyclodextrins using high-performance liquid chromatography.  |  Flood, KG., et al. 2000. J Chromatogr A. 903: 49-65. PMID: 11153955
  2. Comparison of the retention characteristics of different pseudostationary phases for microemulsion and micellar electrokinetic chromatography of betamethasone and derivatives.  |  Lucangioli, SE., et al. 2003. Electrophoresis. 24: 984-91. PMID: 12658686
  3. Topical FK506 as immunoprophylaxis after allogeneic penetrating normal-risk keratoplasty: a randomized clinical pilot study.  |  Reinhard, T., et al. 2005. Transpl Int. 18: 193-7. PMID: 15691272
  4. Matching of the minor histocompatibility antigen HLA-A1/H-Y may improve prognosis in corneal transplantation.  |  Böhringer, D., et al. 2006. Transplantation. 82: 1037-41. PMID: 17060851
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  6. Investigation of temperature-responsivity and aqueous chromatographic characteristics of a thermo-responsive monolithic column.  |  Liu, H., et al. 2011. Talanta. 85: 1193-8. PMID: 21726758
  7. Polymeric nanoparticles modified with fatty acids encapsulating betamethasone for anti-inflammatory treatment.  |  Silva, CO., et al. 2015. Int J Pharm. 493: 271-84. PMID: 26222745
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  9. Acid-Sensitive Sheddable PEGylated, Mannose-Modified Nanoparticles Increase the Delivery of Betamethasone to Chronic Inflammation Sites in a Mouse Model.  |  O'Mary, HL., et al. 2017. Mol Pharm. 14: 1929-1937. PMID: 28463518
  10. Pharmaceutically active compounds (PhACs) in surface sediments of the Jiaozhou Bay, north China.  |  Peng, Q., et al. 2020. Environ Pollut. 266: 115245. PMID: 32717590
  11. Simultaneous determination of betamethasone, betamethasone acetate and hydrocortisone in biological fluids using high-performance liquid chromatography.  |  Petersen, MC., et al. 1980. J Chromatogr. 183: 131-9. PMID: 7400271
  12. General high-performance liquid chromatographic procedures for the rapid screening of natural and synthetic corticosteroids.  |  Valvo, L., et al. 1994. J Pharm Biomed Anal. 12: 805-10. PMID: 7918783
  13. The effects of betamethasone derivatives on endotoxin-induced uveitis in rats.  |  Tsuji, F., et al. 1997. Exp Eye Res. 64: 31-6. PMID: 9093018
  14. Development an automated and high-throughput analytical platform for screening 39 glucocorticoids in animal-derived food for doping control  |  Yonghuan Yan a, Lianfeng Ai b, Haichao Zhang b, Weijun Kang a, Yan Zhang c, Kaoqi Lian a. 2021. Microchemical Journal. 165.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Betamethasone 21-acetate, 500 mg

sc-227353
500 mg
$240.00