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Betaine Aldehyde Chloride (CAS 7758-31-8)

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Alternate Names:
(Formylmethyl)trimethylammonium chloride
Application:
Betaine Aldehyde Chloride is an intermediate in the enzymatic oxidation of choline to betaine
CAS Number:
7758-31-8
Molecular Weight:
137.61
Molecular Formula:
C5H12ClNO
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Betaine aldehyde chloride is an organic compound found in various biological systems. It is involved in the biosynthesis of the osmoprotectant glycine betaine, which helps protect cells from osmotic stress. Betaine aldehyde chloride is a key intermediate in the pathway that converts choline to glycine betaine. This conversion is important for maintaining cellular osmotic balance and protecting cells from environmental stress. Betaine aldehyde chloride is produced by the enzyme betaine aldehyde dehydrogenase, which catalyzes the oxidation of betaine aldehyde to glycine betaine. This enzyme is found in a wide range of organisms, from bacteria to plants to animals, highlighting the importance of betaine aldehyde chloride in cellular physiology.


Betaine Aldehyde Chloride (CAS 7758-31-8) References

  1. Steady-state kinetic mechanism of the NADP+- and NAD+-dependent reactions catalysed by betaine aldehyde dehydrogenase from Pseudomonas aeruginosa.  |  Velasco-García, R., et al. 2000. Biochem J. 352 Pt 3: 675-83. PMID: 11104673
  2. Enhanced stress tolerance in Escherichia coli and Nicotiana tabacum expressing a betaine aldehyde dehydrogenase/choline dehydrogenase fusion protein.  |  Yilmaz, JL. and Bülow, L. 2002. Biotechnol Prog. 18: 1176-82. PMID: 12467448
  3. Purification and properties of betaine aldehyde dehydrogenase with high affinity for NADP from Arthrobacter globiformis.  |  Mori, N., et al. 2002. J Biosci Bioeng. 93: 130-5. PMID: 16233177
  4. Mechanistic studies of choline oxidase with betaine aldehyde and its isosteric analogue 3,3-dimethylbutyraldehyde.  |  Fan, F., et al. 2006. Biochemistry. 45: 1979-86. PMID: 16460045
  5. Enzymatic characterization of peroxisomal and cytosolic betaine aldehyde dehydrogenases in barley.  |  Fujiwara, T., et al. 2008. Physiol Plant. 134: 22-30. PMID: 18429940
  6. Oxidative pathway of choline to betaine in the soluble fraction prepared from Arthrobacter globiformis.  |  Ikuta, S., et al. 1977. J Biochem. 82: 157-63. PMID: 197073
  7. Molecular imaging of adrenal gland by desorption electrospray ionization mass spectrometry.  |  Wu, C., et al. 2010. Analyst. 135: 28-32. PMID: 20024177
  8. Betaine aldehyde dehydrogenase genes from Arabidopsis with different sub-cellular localization affect stress responses.  |  Missihoun, TD., et al. 2011. Planta. 233: 369-82. PMID: 21053011
  9. Inhibition of porcine kidney betaine aldehyde dehydrogenase by hydrogen peroxide.  |  Rosas-Rodríguez, JA., et al. 2010. Redox Rep. 15: 282-7. PMID: 21208528
  10. Exploring the evolutionary route of the acquisition of betaine aldehyde dehydrogenase activity by plant ALDH10 enzymes: implications for the synthesis of the osmoprotectant glycine betaine.  |  Muñoz-Clares, RA., et al. 2014. BMC Plant Biol. 14: 149. PMID: 24884441
  11. Functional and expression analyses of two kinds of betaine aldehyde dehydrogenases in a glycinebetaine-hyperaccumulating graminaceous halophyte, Leymus chinensis.  |  Mitsuya, S., et al. 2015. Springerplus. 4: 202. PMID: 25992309
  12. Isolation and characterization of a salt stress-responsive betaine aldehyde dehydrogenase in Lycium ruthenicum Murr.  |  Liu, Y., et al. 2018. Physiol Plant. 163: 73-87. PMID: 29297198
  13. Betaine-aldehyde dehydrogenase from amaranth leaves efficiently catalyzes the NAD-dependent oxidation of dimethylsulfoniopropionaldehyde to dimethylsulfoniopropionate.  |  Vojtechová, M., et al. 1997. Arch Biochem Biophys. 337: 81-8. PMID: 8990271
  14. Rapid purification and properties of betaine aldehyde dehydrogenase from Pseudomonas aeruginosa.  |  Velasco-García, R., et al. 1999. J Bacteriol. 181: 1292-300. PMID: 9973357

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Betaine Aldehyde Chloride, 10 mg

sc-210907
10 mg
$184.00