β3Gn-T2 Antibody (8G8): sc-134231

β3Gn-T2 Antibody (8G8) is a mouse monoclonal IgG2a kappa light chain antibody that detects β3Gn-T2 of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-β3Gn-T2 antibody (8G8) is available as the non-conjugated format. β3Gn-T2 plays a crucial role in glycan biosynthesis, specifically in the conversion of lacto-N-triose II into lacto-N-tetraose and lacto-N-neotetraose, which are important for cell-cell interactions and signaling. This enzymatic activity is vital for the proper functioning of various biological processes, including immune response and cellular communication. Additionally, β3Gn-T2 can form a heterodimer with β3Gn-T8, enhancing enzymatic activity, which underscores the importance of protein interactions in regulating glycosylation pathways. β3Gn-T2 expression is widespread, contrasting with other members of the beta 1,3-galactosyltransferase family, which exhibit more restricted tissue distribution. Understanding β3Gn-T2 function and interactions is essential for elucidating roles in health and disease, particularly in cancer and chronic infections.

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β3Gn-T2 Antibody (8G8) References:

1. Identification and characterization of three novel beta 1,3-N-acetylglucosaminyltransferases structurally related to the beta 1,3-galactosyltransferase family.  |  Shiraishi, N., et al. 2001. J Biol Chem. 276: 3498-507. PMID: 11042166
2. beta1,3-N-Acetylglucosaminyltransferase-7 (beta3Gn-T7) acts efficiently on keratan sulfate-related glycans.  |  Seko, A. and Yamashita, K. 2004. FEBS Lett. 556: 216-20. PMID: 14706853
3. Core 3 synthase is down-regulated in colon carcinoma and profoundly suppresses the metastatic potential of carcinoma cells.  |  Iwai, T., et al. 2005. Proc Natl Acad Sci U S A. 102: 4572-7. PMID: 15755813
4. Multiple co-transfection and co-expression of human beta-1,3-N-acetylglucosaminyltransferase with human calreticulin chaperone cDNA in a single step in insect cells.  |  Deo, VK. and Park, EY. 2006. Biotechnol Appl Biochem. 43: 129-35. PMID: 16277601
5. Helicobacter pylori induces beta3GnT5 in human gastric cell lines, modulating expression of the SabA ligand sialyl-Lewis x.  |  Marcos, NT., et al. 2008. J Clin Invest. 118: 2325-36. PMID: 18483624
6. Activation of beta1,3-N-acetylglucosaminyltransferase-2 (beta3Gn-T2) by beta3Gn-T8. Possible involvement of beta3Gn-T8 in increasing poly-N-acetyllactosamine chains in differentiated HL-60 cells.  |  Seko, A. and Yamashita, K. 2008. J Biol Chem. 283: 33094-100. PMID: 18826941