β2B Tubulin Antibody (AT5B3): sc-517430

β2B Tubulin Antibody (AT5B3) is a mouse monoclonal IgG2a kappa light chain antibody that detects β2B Tubulin in mouse, rat, and human samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). anti-β2B Tubulin antibody (AT5B3) is available in a non-conjugated form, specifically designed for versatile applications in research. β2B Tubulin, also known as TUBB2B, is a 445 amino acid protein that forms a heterodimer with α-tubulin, playing a crucial role in the assembly and stability of microtubules, which are essential for various cellular functions, including maintaining cell shape, enabling intracellular transport, and facilitating cell division. β2B Tubulin presence in the nuclei and nucleoplasm highlights potential involvement in nuclear processes, which is significant given that microtubules are not only structural components but also play roles in signaling pathways and cellular organization. Notably, β2B Tubulin overexpression has been linked to nonsmall cell lung carcinoma, indicating potential role in tumorigenesis and making β2B Tubulin a valuable target for cancer research. β2B Tubulin (AT5B3) antibody serves as an important tool for studying the intricate mechanisms of cell biology and disease through interactions with various proteins involved in cytoskeletal dynamics.

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β2B Tubulin Antibody (AT5B3) References:

1. Presence of the betaII isotype of tubulin in the nuclei of cultured mesangial cells from rat kidney.  |  Walss, C., et al. 1999. Cell Motil Cytoskeleton. 42: 274-84. PMID: 10223634
2. Identification of betaIII- and betaIV-tubulin isotypes in cold-adapted microtubules from Atlantic cod (Gadus morhua): antibody mapping and cDNA sequencing.  |  Modig, C., et al. 1999. Cell Motil Cytoskeleton. 42: 315-30. PMID: 10223637
3. Delta-tubulin and epsilon-tubulin: two new human centrosomal tubulins reveal new aspects of centrosome structure and function.  |  Chang, P. and Stearns, T. 2000. Nat Cell Biol. 2: 30-5. PMID: 10620804
4. Microtubule-associated parameters as predictive markers of docetaxel activity in advanced breast cancer patients: results of a pilot study.  |  Bernard-Marty, C., et al. 2002. Clin Breast Cancer. 3: 341-5. PMID: 12533264
5. Alpha-, beta-, and gamma-tubulins: sequence comparisons and structural constraints.  |  Burns, RG. 1991. Cell Motil Cytoskeleton. 20: 181-9. PMID: 1773446
6. Beta-tubulin isotype classes II and V expression patterns in nonsmall cell lung carcinomas.  |  Cucchiarelli, V., et al. 2008. Cell Motil Cytoskeleton. 65: 675-85. PMID: 18613117
7. Evolutionary history of a multigene family: an expressed human beta-tubulin gene and three processed pseudogenes.  |  Lee, MG., et al. 1983. Cell. 33: 477-87. PMID: 6688039
8. Multiple forms of tubulin: different gene products and covalent modifications.  |  Ludueña, RF. 1998. Int Rev Cytol. 178: 207-75. PMID: 9348671
9. Expression of amino- and carboxyl-terminal gamma- and alpha-tubulin mutants in cultured epithelial cells.  |  Leask, A. and Stearns, T. 1998. J Biol Chem. 273: 2661-8. PMID: 9446570

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-β2B Tubulin Antibody (AT5B3) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-β2B Tubulin Antibody (AT5B3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

β2B Tubulin Antibody (AT5B3) Specifications

Alternate Product Name: beta tubulin 2B

Product Clone Name: AT5B3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 1-445

Epitope Target: β2B Tubulin

Epitope Species: human

Product Reactivity/Detection: β2B Tubulin

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide, 0.1% gelatin and 1% glycerol

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for β2B Tubulin Antibody (AT5B3): N/A