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β-Zearalenol (CAS 71030-11-0)

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Application:
β-Zearalenol is a synthetic derivative of the macrolactone mycotoxin zearalenone
CAS Number:
71030-11-0
Purity:
≥95%
Molecular Weight:
320.38
Molecular Formula:
C18H24O5
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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β-Zearalenol is a mycotoxin that functions as an estrogenic compound, binding to estrogen receptors in cells. It acts as an agonist, activating these receptors and initiating estrogenic signaling pathways within the cell. β-Zearalenol′s mechanism of action involves interacting with the estrogen receptor, leading to the modulation of gene expression and cellular responses associated with estrogen signaling. By binding to the estrogen receptor, β-Zearalenol may influence various cellular processes and functions regulated by estrogen, potentially impacting cell growth, differentiation, and proliferation. Its ability to mimic the effects of endogenous estrogen allows it to play a role in studying the mechanisms of estrogen signaling and its impact on cellular physiology. In experimental applications, β-Zearalenol is utilized to investigate the specific molecular and cellular effects of estrogen receptor activation, providing insights into the role of estrogenic compounds in biological systems.


β-Zearalenol (CAS 71030-11-0) References

  1. Zearalenone and Its Derivatives α-Zearalenol and β-Zearalenol Decontamination by Saccharomyces cerevisiae Strains Isolated from Bovine Forage.  |  Keller, L., et al. 2015. Toxins (Basel). 7: 3297-308. PMID: 26308051
  2. Activation of ER stress and apoptosis by α- and β-zearalenol in HCT116 cells, protective role of Quercetin.  |  Ben Salem, I., et al. 2016. Neurotoxicology. 53: 334-342. PMID: 26584763
  3. Crocin protects human embryonic kidney cells (HEK293) from α- and β-Zearalenol-induced ER stress and apoptosis.  |  Ben Salem, I., et al. 2016. Environ Sci Pollut Res Int. 23: 15504-14. PMID: 27121014
  4. Synthesis of Mono- and Di-Glucosides of Zearalenone and α-/β-Zearalenol by Recombinant Barley Glucosyltransferase HvUGT14077.  |  Michlmayr, H., et al. 2017. Toxins (Basel). 9: PMID: 28208765
  5. Dispositions and tissue residue of zearalenone and its metabolites α-zearalenol and β-zearalenol in broilers.  |  Buranatragool, K., et al. 2015. Toxicol Rep. 2: 351-356. PMID: 28962368
  6. Estrogenic activity of zearalenone, α-zearalenol and β-zearalenol assessed using the E-screen assay in MCF-7 cells.  |  Tatay, E., et al. 2018. Toxicol Mech Methods. 28: 239-242. PMID: 29057713
  7. Interactions of zearalenone and its reduced metabolites α-zearalenol and β-zearalenol with serum albumins: species differences, binding sites, and thermodynamics.  |  Faisal, Z., et al. 2018. Mycotoxin Res. 34: 269-278. PMID: 30014206
  8. Insights into In Vivo Absolute Oral Bioavailability, Biotransformation, and Toxicokinetics of Zearalenone, α-Zearalenol, β-Zearalenol, Zearalenone-14-glucoside, and Zearalenone-14-sulfate in Pigs.  |  Catteuw, A., et al. 2019. J Agric Food Chem. 67: 3448-3458. PMID: 30807145
  9. Melatonin alleviates β-zearalenol and HT-2 toxin-induced apoptosis and oxidative stress in bovine ovarian granulosa cells.  |  Yang, F., et al. 2019. Environ Toxicol Pharmacol. 68: 52-60. PMID: 30870695
  10. Understanding the Toxin Effects of β-Zearalenol and HT-2 on Bovine Granulosa Cells Using iTRAQ-Based Proteomics.  |  Li, L., et al. 2020. Animals (Basel). 10: PMID: 31941148
  11. Protective Effects of the Hydroethanolic Extract of Fridericia chica on Undifferentiated Human Neuroblastoma Cells Exposed to α-Zearalenol (α-ZEL) and β-Zearalenol (β-ZEL).  |  Alvarez-Ortega, N., et al. 2021. Toxins (Basel). 13: PMID: 34822532
  12. Cytoprotective, Antiproliferative, and Anti-Oxidant Potential of the Hydroethanolic Extract of Fridericia chica Leaves on Human Cancer Cell Lines Exposed to α- and β-Zearalenol.  |  Alvarez-Ortega, N., et al. 2023. Toxins (Basel). 15: PMID: 36668856
  13. Detection and quantification of zearalenone and its modified forms in enzymatically treated oat and wheat flour.  |  Pascari, X., et al. 2023. J Food Sci Technol. 60: 1367-1375. PMID: 36936126
  14. Occurrence of zearalenone and its major metabolites in cereal flour from Korea.  |  Lijalem, YG., et al. 2023. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 40: 675-687. PMID: 37011037

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

β-Zearalenol, 5 mg

sc-224448
5 mg
$98.00

β-Zearalenol, 10 mg

sc-224448A
10 mg
$190.00

Hello, in the CoA of sc-224448 lot number K0915, I need to know what does "hydrate content" mean, is it the same as "water content"? I want to know if to prepare a solution I have to affect the weight with this data, Thanks,

Asked by: Anonymous
Thank you for your question. Yes, hydrate content on the CoA refers to water content by Karl Fischer. This should be taken into account for calculations.
Answered by: Technical Support
Date published: 2019-06-24
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Rated 4 out of 5 by from I will rate this product a 4 and rate 5I will rate this product a 4 and rate 5 for your logistics, customer service and support.
Date published: 2015-04-20
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β-Zearalenol is rated 4.0 out of 5 by 1.
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