Molecular structure of β-Secretase Inhibitor IV, CAS Number: 797035-11-1
β-Secretase Inhibitor IV (CAS 797035-11-1)
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Alternate Names:
5HA; 3-N-[(2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-yl]-5-[methyl(methylsulfonyl)amino]-1-N-[(1R)-1-phenylethyl]benzene-1,3-dicarboxamide
Application:
β-Secretase Inhibitor IV is a compound that binds to the active site of BACE-1 and potently blocks its proteolytic activity
CAS Number:
797035-11-1
Purity:
≥95%
Molecular Weight:
578.72
Molecular Formula:
C31H38N4O5S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
β-Secretase Inhibitor IV, a cell-permeable isophthalamide compound containing a hydroxyethylamine motif which binds to BACE-1 active site and potently blocks its proteolytic activity. The compound displays greater selectivity over other aspartyl proteases. beta-Secretase Inhibitor IV is an inhibitor of BACE and BACE2.
β-Secretase Inhibitor IV (CAS 797035-11-1) References
- Inhibition of amyloid beta-peptide production by blockage of beta-secretase cleavage site of amyloid precursor protein. | Na, CH., et al. 2007. J Neurochem. 101: 1583-95. PMID: 17542811
- Thiamine deficiency increases β-secretase activity and accumulation of β-amyloid peptides. | Zhang, Q., et al. 2011. Neurobiol Aging. 32: 42-53. PMID: 19233513
- Comparison of pharmacological modulation of APP metabolism in primary chicken telencephalic neurons and in a human neuroglioma cell line. | Czvitkovich, S., et al. 2011. J Mol Neurosci. 43: 257-67. PMID: 20603724
- Anti-Aβ drug screening platform using human iPS cell-derived neurons for the treatment of Alzheimer's disease. | Yahata, N., et al. 2011. PLoS One. 6: e25788. PMID: 21984949
- S-Adenosylhomocysteine enhances DNA damage through increased β-amyloid formation and inhibition of the DNA-repair enzyme OGG1b in microglial BV-2 cells. | Lin, HC., et al. 2011. Toxicology. 290: 342-9. PMID: 22064374
- β- but not γ-secretase proteolysis of APP causes synaptic and memory deficits in a mouse model of dementia. | Tamayev, R., et al. 2012. EMBO Mol Med. 4: 171-9. PMID: 22170863
- BACE1 inhibition induces a specific cerebrospinal fluid β-amyloid pattern that identifies drug effects in the central nervous system. | Mattsson, N., et al. 2012. PLoS One. 7: e31084. PMID: 22328928
- From BACE1 inhibitor to multifunctionality of tryptoline and tryptamine triazole derivatives for Alzheimer's disease. | Jiaranaikulwanitch, J., et al. 2012. Molecules. 17: 8312-33. PMID: 22781443
- β-Secretase (BACE1) inhibition causes retinal pathology by vascular dysregulation and accumulation of age pigment. | Cai, J., et al. 2012. EMBO Mol Med. 4: 980-91. PMID: 22903875
- Soluble amyloid precursor protein-α rescues age-linked decline in neural progenitor cell proliferation. | Demars, MP., et al. 2013. Neurobiol Aging. 34: 2431-40. PMID: 23683827
- Design, synthesis and biological evaluation of tasiamide B derivatives as BACE1 inhibitors. | Liu, J., et al. 2015. Bioorg Med Chem. 23: 1963-74. PMID: 25842365
- Increased Plasma Beta-Secretase 1 May Predict Conversion to Alzheimer's Disease Dementia in Individuals With Mild Cognitive Impairment. | Shen, Y., et al. 2018. Biol Psychiatry. 83: 447-455. PMID: 28359566
- APLP1 is endoproteolytically cleaved by γ-secretase without previous ectodomain shedding. | Schauenburg, L., et al. 2018. Sci Rep. 8: 1916. PMID: 29382944
- Inkjet printing-based β-secretase fluorescence resonance energy transfer (FRET) assay for screening of potential β-secretase inhibitors of Alzheimer's disease. | Lee, J., et al. 2018. Anal Chim Acta. 1022: 89-95. PMID: 29729742
- The Amyloid Precursor Protein Plays Differential Roles in the UVA Resistance and Proliferation of Human Retinal Pigment Epithelial Cells. | Sultan, F. and Parkin, ET. 2022. Protein Pept Lett. 29: 313-327. PMID: 35176974
Inhibitor of:
BACE, and BACE2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
β-Secretase Inhibitor IV, 1 mg | sc-222304 | 1 mg | $378.00 |