β-Muricholic Acid (CAS 2393-59-1)
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β-Muricholic acid is a bile acid, a component of bile that plays a role in the digestion and absorption of fats and fat-soluble vitamins in the intestines. Unlike the more prevalent bile acids, such as cholic acid and chenodeoxycholic acid, β-muricholic acid exhibits different solubility and receptor affinity characteristics, which can influence lipid metabolism, glucose regulation, and the gut microbiota composition. β-Muricholic Acid can be found in urine. It is used in studies of down regulation of transporter protein via ubiquitin dependent protein degradation. Furthermore, the interaction of bile acids like β-muricholic acid with nuclear receptors (e.g., FXR) and membrane receptors (e.g., TGR5) in the liver and intestines is a subject of considerable research interest.
β-Muricholic Acid (CAS 2393-59-1) References
- Formation of hyodeoxycholic acid from muricholic acid and hyocholic acid by an unidentified gram-positive rod termed HDCA-1 isolated from rat intestinal microflora. | Eyssen, HJ., et al. 1999. Appl Environ Microbiol. 65: 3158-63. PMID: 10388717
- Effect of beta-muricholic acid on the prevention and dissolution of cholesterol gallstones in C57L/J mice. | Wang, DQ. and Tazuma, S. 2002. J Lipid Res. 43: 1960-8. PMID: 12401895
- Tauro-β-muricholic acid restricts bile acid-induced hepatocellular apoptosis by preserving the mitochondrial membrane potential. | Denk, GU., et al. 2012. Biochem Biophys Res Commun. 424: 758-64. PMID: 22809502
- By-products in the analysis of beta-muricholic acid in biological samples as methyl ester triacetate. | Janssen, G., et al. 1989. Steroids. 53: 677-93. PMID: 2815149
- Identification of urine tauro-β-muricholic acid as a promising biomarker in Polygoni Multiflori Radix-induced hepatotoxicity by targeted metabolomics of bile acids. | Zhao, DS., et al. 2017. Food Chem Toxicol. 108: 532-542. PMID: 28237774
- Ursodeoxycholic Acid Suppresses Lipogenesis in Mouse Liver: Possible Role of the Decrease in β-Muricholic Acid, a Farnesoid X Receptor Antagonist. | Fujita, K., et al. 2017. Lipids. 52: 335-344. PMID: 28315136
- Stress can attenuate hepatic lipid accumulation via elevation of hepatic β-muricholic acid levels in mice with nonalcoholic steatohepatitis. | Takada, S., et al. 2021. Lab Invest. 101: 193-203. PMID: 36775485
- beta-Muricholic acid; potentiometric and cholesterol-dissolving properties. | Montet, JC., et al. 1987. Biochim Biophys Acta. 918: 1-10. PMID: 3828364
- Metabolism of beta-muricholic acid in man. | Sacquet, E., et al. 1985. Steroids. 45: 411-26. PMID: 3834660
- The formation of lithocholic acid, chenodeoxycholic acid and alpha- and beta-muricholic acids from cholesterol incubated with rat-liver mitochondria. | Mitropoulos, KA. and Myant, NB. 1967. Biochem J. 103: 472-9. PMID: 6047622
- A radioimmunoassay for tauro-beta-muricholic acid suitable for use with isolated rat liver cells. | Botham, KM., et al. 1983. FEBS Lett. 151: 19-21. PMID: 6825837
- Delta 22-beta-muricholic acid in monoassociated rats and conventional rats. | Kayahara, T., et al. 1994. Lipids. 29: 289-96. PMID: 8177022
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
β-Muricholic Acid, 1 mg | sc-477731 | 1 mg | $406.00 | |||
β-Muricholic Acid, 5 mg | sc-477731A | 5 mg | $721.00 | |||
β-Muricholic Acid, 10 mg | sc-477731B | 10 mg | $1196.00 | |||
β-Muricholic Acid, 25 mg | sc-477731C | 25 mg | $3006.00 |