Molecular structure of β-Melanocyte stimulating hormone, human, CAS Number: 17908-57-5
β-Melanocyte stimulating hormone, human (CAS 17908-57-5)
Alternate Names:
β-MSH
Application:
β-Melanocyte stimulating hormone, human is a key ligand acting on melanocortin-4 receptors
CAS Number:
17908-57-5
Molecular Weight:
2660.92
Molecular Formula:
C118H174N34O35S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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β-Melanocyte stimulating hormone, human (β-MSH) is a hormone derived from proopiomelanocortin (POMC), a precursor peptide hormone. β-Melanocyte stimulating hormone, human specifically acts on melanocortin receptors, primarily the melanocortin-4 receptor (MC4R), which is involved in the regulation of appetite and energy homeostasis. β-Melanocyte stimulating hormone, human plays a role in regulating melanogenesis, the production of melanin pigment in the skin, hair, and eyes. It stimulates the production and release of melanin by melanocytes, which are specialized cells responsible for melanin synthesis.
β-Melanocyte stimulating hormone, human (CAS 17908-57-5) References
- Antagonism of chlorpromazine by beta-melanocyte stimulating hormone (beta-MSH). | KRIVOY, WA. and GUILLEMIN, R. 1962. Experientia. 18: 20-1. PMID: 14459759
- Beta-melanocyte-stimulating hormone potently reduces appetite via the hypothalamus in chicks. | Smith, ML., et al. 2008. J Neuroendocrinol. 20: 220-6. PMID: 18088360
- The influence of alpha-, beta-, and gamma-melanocyte stimulating hormone on acetaminophen induced liver lesions in male CBA mice. | Blagaić, V., et al. 2010. Molecules. 15: 1232-41. PMID: 20335976
- Human beta-melanocyte-stimulating hormone revisited. | Bertagna, X., et al. 1986. Proc Natl Acad Sci U S A. 83: 9719-23. PMID: 2432601
- Comparative Functional Alanine Positional Scanning of the α-Melanocyte Stimulating Hormone and NDP-Melanocyte Stimulating Hormone Demonstrates Differential Structure-Activity Relationships at the Mouse Melanocortin Receptors. | Todorovic, A., et al. 2016. ACS Chem Neurosci. 7: 984-94. PMID: 27135265
- The orphan G protein-coupled receptor GPR139 is activated by the peptides: Adrenocorticotropic hormone (ACTH), α-, and β-melanocyte stimulating hormone (α-MSH, and β-MSH), and the conserved core motif HFRW. | Nøhr, AC., et al. 2017. Neurochem Int. 102: 105-113. PMID: 27916541
- Melanocortin-4 Receptor Signalling: Importance for Weight Regulation and Obesity Treatment. | Kühnen, P., et al. 2019. Trends Mol Med. 25: 136-148. PMID: 30642682
- The anorexigenic effect of beta-melanocyte-stimulating hormone involves corticotrophin-releasing factor and mesotocin in birds. | Cao, C., et al. 2020. Neurosci Lett. 736: 135282. PMID: 32738351
- Obesity, POMC, and POMC-processing Enzymes: Surprising Results From Animal Models. | Lindberg, I. and Fricker, LD. 2021. Endocrinology. 162: PMID: 34333593
- Adrenocorticotrophic and melanocyte-stimulating peptides in the human pituitary. | Scott, AP. and Lowry, PJ. 1974. Biochem J. 139: 593-602. PMID: 4368382
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
β-Melanocyte stimulating hormone, human, 1 mg | sc-394423 | 1 mg | $316.00 |