β-glucosidase Antibody (C-2): sc-365745
- β-glucosidase Antibody (C-2) is a mouse monoclonal IgG1 κ, cited in 5 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 67-95 near the N-terminus of β-glucosidase of human origin
- recommended for detection of β-glucosidase of human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for β-glucosidase Antibody (C-2) for WB applications. These reagents are now offered in bundles with β-glucosidase Antibody (C-2) (see ordering information below).
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β-glucosidase Antibody (C-2) is a mouse monoclonal IgG1 antibody that detects β-glucosidase in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). β-glucosidase plays a crucial role in the hydrolysis of β-D-glucosides and β-D-galactosides, primarily in the liver, and is essential for the metabolism of complex carbohydrates. The enzyme′s function is particularly important as defects in β-glucosidase lead to Gaucher disease, a genetic disorder characterized by the harmful accumulation of glucosylceramide in the reticuloendothelial system, which can result in severe health complications. Furthermore, β-glucosidase is integral to the absorption of dietary flavonoid glycosides, as β-glucosidase facilitates a vital deglycosylation step in the intestinal epithelium, thereby influencing the bioavailability of these beneficial compounds. anti-β-glucosidase antibody (C-2) is an invaluable tool for researchers studying the enzyme′s role in metabolic pathways and implications in various diseases, including Gaucher disease.
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β-glucosidase Antibody (C-2) References:
- Distribution of beta-glucosidase and beta-glucuronidase activity and of beta-glucuronidase gene gus in human colonic bacteria. | Dabek, M., et al. 2008. FEMS Microbiol Ecol. 66: 487-95. PMID: 18537837
- Human acid beta-glucosidase: use of sphingosyl and N-alkyl-glucosylamine inhibitors to investigate the properties of the active site. | Greenberg, P., et al. 1990. Biochim Biophys Acta. 1039: 12-20. PMID: 2141287
- β-Glucosidase activities of lactic acid bacteria: mechanisms, impact on fermented food and human health. | Michlmayr, H. and Kneifel, W. 2014. FEMS Microbiol Lett. 352: 1-10. PMID: 24330034
- Imino- and Azasugar Protonation Inside Human Acid β-Glucosidase, the Enzyme that is Defective in Gaucher Disease. | Matassini, C., et al. 2020. Angew Chem Int Ed Engl. 59: 10466-10469. PMID: 32191378
- Bifidobacterium β-Glucosidase Activity and Fermentation of Dietary Plant Glucosides Is Species and Strain Specific. | Modrackova, N., et al. 2020. Microorganisms. 8: PMID: 32503148
- Nanomolar β-glucosidase and β-galactosidase inhibition by enantiomeric α-1-C-alkyl-1,4-dideoxy-1,4-imino-arabinitol derivatives. | Zi, D., et al. 2023. Eur J Med Chem. 247: 115056. PMID: 36603505
- Design of a stable human acid-β-glucosidase: towards improved Gaucher disease therapy and mutation classification. | Pokorna, S., et al. 2023. FEBS J. 290: 3383-3399. PMID: 36808692
- Synthesis and Biological Evaluation of Deoxycyclophellitols as Human Retaining β-Glucosidase Inhibitors. | Radchenko, Y., et al. 2024. Chemistry. 30: e202402988. PMID: 39305182
- Analysis of human acid beta-glucosidase by site-directed mutagenesis and heterologous expression. | Grace, ME., et al. 1994. J Biol Chem. 269: 2283-91. PMID: 8294487
- Human acid beta-glucosidase. N-glycosylation site occupancy and the effect of glycosylation on enzymatic activity. | Berg-Fussman, A., et al. 1993. J Biol Chem. 268: 14861-6. PMID: 8325864
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
β-glucosidase Antibody (C-2) | sc-365745 | 200 µg/ml | $322.00 | |||
β-glucosidase Antibody (C-2): m-IgG Fc BP-HRP Bundle | sc-540364 | 200 µg Ab; 10 µg BP | $361.00 | |||
β-glucosidase Antibody (C-2): m-IgG1 BP-HRP Bundle | sc-542071 | 200 µg Ab; 20 µg BP | $361.00 | |||
β-glucosidase (C-2) Neutralizing Peptide | sc-365745 P | 100 µg/0.5 ml | $69.00 |