β-Estradiol 17-(β-D-glucuronide) sodium salt (CAS 15087-02-2)
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β-Estradiol 17-(β-D-glucuronide) sodium salt is a glucocorticosteroid estrogen metabolite formed in the liver, and excreted in bile. β-Estradiol 17-(β-D-glucuronide) sodium salt functions as a substrate of the multidrug resistance protein 2 (MRP2), and with its cholestatic agentry, β-Estradiol 17-(β-D-glucuronide) sodium salt can actually decrease bile flow. After binding to the MRP2 site, β-Estradiol 17-(β-D-glucuronide) sodium salt may act to bind to an allosteric site that activates its own transport via MRP2, and the transport of other MRP2 substrates including non-cholestatic estrogen metabolites. β-Estradiol 17-(β-D-glucuronide) sodium salt has also been observed being transported by MDR1, MRP1, MRP3, MRP4, MRP7, ABCG2, and rat organic anion-transporting polypeptides 1-4.
β-Estradiol 17-(β-D-glucuronide) sodium salt (CAS 15087-02-2) References
- Characterization of the zebrafish Ugt repertoire reveals a new class of drug-metabolizing UDP glucuronosyltransferases. | Wang, Y., et al. 2014. Mol Pharmacol. 86: 62-75. PMID: 24728488
- Biomagnification of endocrine disrupting chemicals (EDCs) by Pleuronectes yokohamae: Does P. yokohamae accumulate dietary EDCs? | Nurulnadia, MY., et al. 2016. Chemosphere. 144: 185-92. PMID: 26363319
- In Vitro Glucuronidation of Caribbean Ciguatoxins in Fish: First Report of Conjugative Ciguatoxin Metabolites. | Gwinn, JK., et al. 2021. Chem Res Toxicol. 34: 1910-1925. PMID: 34319092
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
β-Estradiol 17-(β-D-glucuronide) sodium salt, 5 mg | sc-227985 | 5 mg | $106.00 | |||
β-Estradiol 17-(β-D-glucuronide) sodium salt, 10 mg | sc-227985A | 10 mg | $187.00 | |||
β-Estradiol 17-(β-D-glucuronide) sodium salt, 25 mg | sc-227985B | 25 mg | $539.00 |