β-endorphin Antibody (B31.15): sc-51680

β-endorphin Antibody (B31.15) is a mouse monoclonal IgG1 antibody specifically designed to detect β-endorphin, a 31-amino-acid peptide derived from the precursor protein pro-opiomelanocortin (POMC). Anti-β-endorphin antibody (B31.15) reacts with human β-endorphin in immunofluorescence (IF) and immunohistochemistry with paraffin-embedded sections (IHCP), making β-endorphin (B31.15) antibody a valuable tool for studying the expression and localization of this peptide. β-endorphin, also known as beta-endorphin or β-end, is an endogenous opioid neuropeptide that plays a crucial role in pain modulation, stress response, and immune system regulation. Produced primarily in the neurons of the hypothalamus and the pituitary gland, β-endorphin binds to opioid receptors to exert analgesic and euphoric effects. POMC undergoes extensive tissue-specific post-translational processing to yield several active peptides, including β-endorphin, adrenocorticotropic hormone (ACTH), and melanocyte-stimulating hormones (MSH). Mutations or defects in the POMC gene can lead to conditions like POMC deficiency, characterized by adrenal insufficiency, obesity, and altered pigmentation such as red hair. Understanding the function of β-endorphin is essential for research into pain management, addiction, mood disorders, and metabolic diseases. β-endorphin monoclonal antibody (B31.15) provides researchers with a reliable means to detect and study this important peptide, facilitating advances in neuroscience and endocrinology.

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β-endorphin Antibody (B31.15) References:

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2. Hormone and glucose signalling in POMC and AgRP neurons.  |  Belgardt, BF., et al. 2009. J Physiol. 587: 5305-14. PMID: 19770186
3. The melanocortin system in articular chondrocytes: melanocortin receptors, pro-opiomelanocortin, precursor proteases, and a regulatory effect of alpha-melanocyte-stimulating hormone on proinflammatory cytokines and extracellular matrix components.  |  Grässel, S., et al. 2009. Arthritis Rheum. 60: 3017-27. PMID: 19790046
4. Growth inhibition of thyroid follicular cell-derived cancers by the opioid growth factor (OGF) - opioid growth factor receptor (OGFr) axis.  |  McLaughlin, PJ., et al. 2009. BMC Cancer. 9: 369. PMID: 19835629
5. NF-kappaB activation in hypothalamic pro-opiomelanocortin neurons is essential in illness- and leptin-induced anorexia.  |  Jang, PG., et al. 2010. J Biol Chem. 285: 9706-9715. PMID: 20097762
6. Dephosphorylation/inactivation of tyrosine hydroxylase at the median eminence of the hypothalamus is required for suckling-induced prolactin and adrenocorticotrop hormone responses.  |  Fehér, P., et al. 2010. Brain Res Bull. 82: 141-5. PMID: 20170714
7. Comprehensive analysis of common genetic variation in 61 genes related to steroid hormone and insulin-like growth factor-I metabolism and breast cancer risk in the NCI breast and prostate cancer cohort consortium.  |  Canzian, F., et al. 2010. Hum Mol Genet. 19: 3873-84. PMID: 20634197
8. Peroxisomal localization of the proopiomelanocortin-derived peptides beta-lipotropin and beta-endorphin.  |  Höftberger, R., et al. 2010. Endocrinology. 151: 4801-10. PMID: 20810565

The preferred ACTH antibody is ACTH Antibody (2F6): sc-69648.