β-defensin 4 Antibody (L13-10-D1): sc-59496

β-defensin 4 Antibody (L13-10-D1) is a mouse monoclonal IgG1 antibody that detects human beta-defensin 4 by western blotting (WB), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). Anti-beta-defensin 4 antibody (L13-10-D1) is available as a non-conjugated format. Beta-defensin 4 plays a crucial role in innate immune response, exhibiting broad-spectrum antimicrobial activity vital for protecting mucosal surfaces from pathogens. Beta-defensin 4 is primarily produced in mucosal epithelia and neutrophils, and expression is developmentally regulated, with highest levels found in testis. Human β-defensin 4 (hBD-4) is expressed in a restricted pattern, suggesting specialized function in specific tissues. Selective expression of hBD-4, along with antimicrobial properties, indicates particular suitability for acting at epithelial locations, providing first-line defense against microbial invasion. Regulation of beta-defensin 4 in rat and mouse highlights evolutionary significance in host defense mechanisms. Beta-defensin 4 monoclonal antibody (L13-10-D1) serves as an essential tool for studying immune responses and potential implications in various diseases.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

β-defensin 4 Antibody (L13-10-D1) References:

1. Mouse beta-defensin 3 is an inducible antimicrobial peptide expressed in the epithelia of multiple organs.  |  Bals, R., et al. 1999. Infect Immun. 67: 3542-7. PMID: 10377137
2. Beta-defensins: linking innate and adaptive immunity through dendritic and T cell CCR6.  |  Yang, D., et al. 1999. Science. 286: 525-8. PMID: 10521347
3. Human beta-defensin 4: a novel inducible peptide with a specific salt-sensitive spectrum of antimicrobial activity.  |  García, JR., et al. 2001. FASEB J. 15: 1819-21. PMID: 11481241
4. Human airway epithelia express a beta-defensin.  |  McCray, PB. and Bentley, L. 1997. Am J Respir Cell Mol Biol. 16: 343-9. PMID: 9070620
5. The human beta-defensin-1 and alpha-defensins are encoded by adjacent genes: two peptide families with differing disulfide topology share a common ancestry.  |  Liu, L., et al. 1997. Genomics. 43: 316-20. PMID: 9268634
6. Structure and mapping of the human beta-defensin HBD-2 gene and its expression at sites of inflammation.  |  Liu, L., et al. 1998. Gene. 222: 237-44. PMID: 9831658
7. A novel mouse beta defensin, Defb2, which is upregulated in the airways by lipopolysaccharide.  |  Morrison, GM., et al. 1999. FEBS Lett. 442: 112-6. PMID: 9923615