β-defensin 2 Antibody (2-RY8): sc-134314

β-defensin 2 Antibody (2-RY8) is a mouse monoclonal IgG1 kappa light chain antibody that detects human beta-defensin 2 by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-beta-defensin 2 antibody (2-RY8) is available in non-conjugated format. Beta-defensin 2 is a crucial component of the innate immune system, functioning primarily as an antimicrobial peptide that provides a first line of defense against pathogens. Beta-defensin 2 is produced in mucosal epithelia and neutrophils, and expression is tightly regulated by inflammatory signals, making beta-defensin 2 an important player in the body′s response to infection. Beta-defensin 2′s ability to disrupt microbial membranes contributes to broad-spectrum antimicrobial activity, which is vital for maintaining mucosal integrity and preventing infections. Additionally, human beta-defensin 2 is the first member of the beta-defensin family that can be locally induced by inflammation, highlighting beta-defensin 2′s role in the immune response. Understanding beta-defensin 2 function is essential for exploring therapeutic strategies aimed at enhancing host defense mechanisms, particularly in conditions where the immune response is compromised.

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β-defensin 2 Antibody (2-RY8) References:

1. Mouse beta-defensin 3 is an inducible antimicrobial peptide expressed in the epithelia of multiple organs.  |  Bals, R., et al. 1999. Infect Immun. 67: 3542-7. PMID: 10377137
2. Beta-defensins: linking innate and adaptive immunity through dendritic and T cell CCR6.  |  Yang, D., et al. 1999. Science. 286: 525-8. PMID: 10521347
3. Expression of human β-defensin-2 in the prostate.  |  Kim, HJ., et al. 2011. BJU Int. 107: 144-9. PMID: 20575976
4. Human β-defensin 2 and protease activated receptor-2 expression in patients with chronic periodontitis.  |  Pereira, AL., et al. 2012. Arch Oral Biol. 57: 1609-14. PMID: 22647427
5. Human β-Defensin 2 in Primary Sclerosing Cholangitis.  |  Chang, C., et al. 2017. Clin Transl Gastroenterol. 8: e80. PMID: 28300822
6. Immunohistochemical study on the distribution of β-defensin 1 and β-defensin 2 throughout the respiratory tract of healthy rats.  |  Masuda, N., et al. 2018. J Vet Med Sci. 80: 395-404. PMID: 29311494
7. Human β-defensin 2 kills Candida albicans through phosphatidylinositol 4,5-bisphosphate-mediated membrane permeabilization.  |  Järvå, M., et al. 2018. Sci Adv. 4: eaat0979. PMID: 30050988
8. Fecal human β-defensin-2 (hBD-2) levels and gut microbiota patterns in preterm neonates with different feeding patterns.  |  Corebima, BIRV., et al. 2019. Iran J Microbiol. 11: 151-159. PMID: 31341570
9. Human airway epithelia express a beta-defensin.  |  McCray, PB. and Bentley, L. 1997. Am J Respir Cell Mol Biol. 16: 343-9. PMID: 9070620
10. The human beta-defensin-1 and alpha-defensins are encoded by adjacent genes: two peptide families with differing disulfide topology share a common ancestry.  |  Liu, L., et al. 1997. Genomics. 43: 316-20. PMID: 9268634
11. Structure and mapping of the human beta-defensin HBD-2 gene and its expression at sites of inflammation.  |  Liu, L., et al. 1998. Gene. 222: 237-44. PMID: 9831658
12. A novel mouse beta defensin, Defb2, which is upregulated in the airways by lipopolysaccharide.  |  Morrison, GM., et al. 1999. FEBS Lett. 442: 112-6. PMID: 9923615

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-β-defensin 2 Antibody (2-RY8) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-β-defensin 2 Antibody (2-RY8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

β-defensin 2 Antibody (2-RY8) Specifications

Alternate Product Name: β-defensin 2

Product Clone Name: 2-RY8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 24-65

Epitope Target: β-defensin 2

Epitope Species: human

Product Reactivity/Detection: β-defensin 2

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for β-defensin 2 Antibody (2-RY8): N/A