β-Aescin (CAS 11072-93-8)
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β-Aescin is a natural compound found in horse chestnut tree seeds (Aesculus hippocastanum). This mixture of saponins consists of sugar molecules bound to a lipophilic aglycone. β-Aescin′s properties, as found in laboratory research, include anti-inflammatory, anti-edematous, and anti-thrombotic attributes on a cellular level, in addition to antioxidant, antifungal, and antiviral qualities. In a research context, β-Aescin′s role in addressing venous diseases and conditions related to lymphedema has been studied. The specific action mechanism of β-Aescin is not entirely known, but it is thought to function by limiting the activity of certain enzymes, like elastase and hyaluronidase, involved in connective tissue breakdown. Additionally, β-Aescin has been observed to decrease capillary permeability.
β-Aescin (CAS 11072-93-8) References
- Effects of beta-aescin on apoptosis induced by transient focal cerebral ischemia in rats. | Hu, XM., et al. 2004. Acta Pharmacol Sin. 25: 1267-75. PMID: 15456527
- Effects of beta-Aescin on the expression of nuclear factor-kappaB and tumor necrosis factor-alpha after traumatic brain injury in rats. | Xiao, GM. and Wei, J. 2005. J Zhejiang Univ Sci B. 6: 28-32. PMID: 15593388
- Beta-aescin: a potent natural inhibitor of proliferation and inducer of apoptosis in human chronic myeloid leukemia K562 cells in vitro. | Niu, YP., et al. 2008. Leuk Lymphoma. 49: 1384-91. PMID: 18452082
- Synergistic effects of beta-aescin and 5-fluorouracil in human hepatocellular carcinoma SMMC-7721 cells. | Ming, ZJ., et al. 2010. Phytomedicine. 17: 575-80. PMID: 20106644
- Effect of beta-aescin extract from Chinese buckeye seed on chronic venous insufficiency. | Yu, Z. and Su, P. 2013. Pharmazie. 68: 428-30. PMID: 23875249
- Cytotoxic effects of four aescin types on human colon adenocarcinoma cell lines. | Seweryn, E., et al. 2014. Nat Prod Commun. 9: 387-90. PMID: 24689224
- β-Aescin at subinhibitory concentration (sub-MIC) enhances susceptibility of Candida glabrata clinical isolates to nystatin. | Franiczek, R., et al. 2015. Med Mycol. 53: 845-51. PMID: 26092104
- The novel role of β-aescin in attenuating CCl4-induced hepatotoxicity in rats. | Singh, H., et al. 2017. Pharm Biol. 55: 749-757. PMID: 28064552
- β-Aescin shows potent antiproliferative activity in osteosarcoma cells by inducing autophagy, ROS generation and mitochondrial membrane potential loss. | Liu, ZR., et al. 2017. J BUON. 22: 1582-1586. PMID: 29332356
- [β-aescin alleviates acute lung injury induced by lipopolysaccharide by inhibiting lipid peroxidation and inflammation in mice]. | Wang, B., et al. 2018. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 34: 600-604. PMID: 30381123
- The Biosurfactant β-Aescin: A Review on the Physico-Chemical Properties and Its Interaction with Lipid Model Membranes and Langmuir Monolayers. | Geisler, R., et al. 2019. Molecules. 25: PMID: 31892278
- Glucocorticoid-Like Activity of Escin: A New Mechanism for an Old Drug. | Gallelli, L., et al. 2021. Drug Des Devel Ther. 15: 699-704. PMID: 33658760
- Beneficial effects of β-escin on muscle regeneration in rat model of skeletal muscle injury. | Sikorska, M., et al. 2021. Phytomedicine. 93: 153791. PMID: 34666284
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
β-Aescin, 250 mg | sc-491651A | 250 mg | $41.00 | |||
β-Aescin, 1 g | sc-491651 | 1 g | $107.00 | |||
β-Aescin, 5 g | sc-491651B | 5 g | $520.00 | |||
β-Aescin, 10 g | sc-491651C | 10 g | $825.00 |