β-Adaptin Antibody (100/1): sc-58226
- β-Adaptin Antibody (100/1) is a mouse monoclonal IgG1 κ, cited in 2 publications, provided at 200 µg/ml
- raised against β-Adaptin of bovine origin
- recommended for detection of β1-Adaptin and β2-Adaptin by WB, IP and IF; also reactive with additional species, including bovine
- m-IgG1 BP-HRP is the preferred secondary detection reagent for β-Adaptin Antibody (100/1) for WB applications. This reagent is now offered in a bundle with β-Adaptin Antibody (100/1) (see ordering information below).
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β-Adaptin Antibody (100/1) is a mouse monoclonal IgG1 antibody that detects β-Adaptin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). β-Adaptin plays a crucial role in the clathrin-mediated endocytosis process, which is essential for the internalization of membrane proteins and lipids, thereby regulating various cellular functions, including nutrient uptake and signal transduction. β-Adaptin is primarily located at the cytoplasmic side of the plasma membrane, where β-Adaptin interacts with clathrin and other adaptor proteins to form clathrin-coated pits, facilitating the formation of vesicles that transport cargo into the cell. Proper functioning of β-Adaptin is vital for maintaining cellular homeostasis and ensuring efficient communication between cells, as disruptions in this process can lead to various diseases, including neurodegenerative disorders and cancer. Anti-β-Adaptin antibody (100/1) is an invaluable tool for researchers studying the dynamics of endocytosis and its implications in health and disease, providing reliable detection and characterization of β-Adaptin in various experimental settings.
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β-Adaptin Antibody (100/1) References:
- Expression of a novel beta adaptin subunit mRNA splice variant in human testes. | Zhang, XD., et al. 2005. Asian J Androl. 7: 179-88. PMID: 15897975
- Beta-adaptin: key molecule for microglial scavenger receptor function under oxidative stress. | Manzano-León, N., et al. 2006. Biochem Biophys Res Commun. 351: 588-94. PMID: 17092488
- Beta-COP, a 110 kd protein associated with non-clathrin-coated vesicles and the Golgi complex, shows homology to beta-adaptin. | Duden, R., et al. 1991. Cell. 64: 649-65. PMID: 1840503
- A coat subunit of Golgi-derived non-clathrin-coated vesicles with homology to the clathrin-coated vesicle coat protein beta-adaptin. | Serafini, T., et al. 1991. Nature. 349: 215-20. PMID: 1898984
- A single β adaptin contributes to AP1 and AP2 complexes and clathrin function in Dictyostelium. | Sosa, RT., et al. 2012. Traffic. 13: 305-16. PMID: 22050483
- A dominant-negative form of Arabidopsis AP-3 β-adaptin improves intracellular pH homeostasis. | Niñoles, R., et al. 2013. Plant J. 74: 557-68. PMID: 23397991
- Absence of a stable secondary structure is not a limitation for photoswitchable inhibitors of β-arrestin/β-Adaptin 2 protein-protein interaction. | Martín-Quirós, A., et al. 2015. Chem Biol. 22: 31-7. PMID: 25615951
- A Novel β-adaptin/c-Myc Complex Formation Modulated by Oxidative Stress in the Control of the Cell Cycle in Macrophages and its Implication in Atherogenesis. | García-González, V. and Mas-Oliva, J. 2017. Sci Rep. 7: 13442. PMID: 29044181
- Characterization of a new member of the human beta-adaptin gene family from chromosome 22q12, a candidate meningioma gene. | Peyrard, M., et al. 1994. Hum Mol Genet. 3: 1393-9. PMID: 7987321
- An immunologically distinct beta-adaptin on tubulovesicles of gastric oxyntic cells. | Okamoto, CT. and Jeng, YY. 1998. Am J Physiol. 275: C1323-9. PMID: 9814981
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
β-Adaptin Antibody (100/1) | sc-58226 | 200 µg/ml | $316.00 | |||
β-Adaptin Antibody (100/1): m-IgG1 BP-HRP Bundle | sc-542604 | 200 µg Ab; 20 µg BP | $354.00 |