Molecular structure of Bestatin Methyl Ester, CAS Number: 65322-89-6
Bestatin Methyl Ester (CAS 65322-89-6)
See product citations (2)
Application:
Bestatin Methyl Ester is an aminopeptidase inhibitor
CAS Number:
65322-89-6
Purity:
≥97%
Molecular Weight:
322.4
Molecular Formula:
C17H26N2O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Bestatin methyl ester is a cell-permeable derivative of Bestatin which displays slightly stronger inhibition of neutral aminopeptidase than Bestatin, but has much weaker activity against basic aminopeptidase. Bestatin methyl ester also augments Fas- or TNF-alpha-induced apoptosis in solid tumor cell lines. Bestatin methyl ester is a synthetic compound derived from the amino acid leucine. It has found application in research exploring the influence of enzymes on proteins.
Bestatin Methyl Ester (CAS 65322-89-6) References
- Induction of apoptosis by bestatin (ubenimex) in human leukemic cell lines. | Sekine, K., et al. 1999. Leukemia. 13: 729-34. PMID: 10374877
- Augmentation of death ligand-induced apoptosis by aminopeptidase inhibitors in human solid tumor cell lines. | Sekine, K., et al. 2001. Int J Cancer. 94: 485-91. PMID: 11745433
- Small molecules destabilize cIAP1 by activating auto-ubiquitylation. | Sekine, K., et al. 2008. J Biol Chem. 283: 8961-8. PMID: 18230607
- Killing of macrophages by anthrax lethal toxin: involvement of the N-end rule pathway. | Wickliffe, KE., et al. 2008. Cell Microbiol. 10: 1352-62. PMID: 18266992
- Gonyauline: a novel endogenous substance shortening the period of the circadian clock of a unicellular alga. | Roenneberg, T., et al. 1991. Experientia. 47: 103-6. PMID: 1999237
- Specific degradation of CRABP-II via cIAP1-mediated ubiquitylation induced by hybrid molecules that crosslink cIAP1 and the target protein. | Okuhira, K., et al. 2011. FEBS Lett. 585: 1147-52. PMID: 21414315
- Bestatin inhibits cell growth, cell division, and spore cell differentiation in Dictyostelium discoideum. | Poloz, Y., et al. 2012. Eukaryot Cell. 11: 545-57. PMID: 22345351
- Protein Knockdown Technology: Application of Ubiquitin Ligase to Cancer Therapy. | Ohoka, N., et al. 2016. Curr Cancer Drug Targets. 16: 136-46. PMID: 26560118
- Molecular Design, Synthesis, and Evaluation of SNIPER(ER) That Induces Proteasomal Degradation of ERα. | Okuhira, K., et al. 2016. Methods Mol Biol. 1366: 549-560. PMID: 26585163
- Discovery of Small Molecules that Induce the Degradation of Huntingtin. | Tomoshige, S., et al. 2017. Angew Chem Int Ed Engl. 56: 11530-11533. PMID: 28703441
- Asymmetric Si-rhodamine scaffolds: rational design of pH-durable protease-activated NIR probes in vivo. | Li, M., et al. 2020. Chem Commun (Camb). 56: 2455-2458. PMID: 31996872
- The impact of intracellular aminopeptidase on C2C12 myoblast proliferation and differentiation. | Osana, S., et al. 2020. Biochem Biophys Res Commun. 524: 608-613. PMID: 32029277
- Inhibitory effects of various synthetic substrates for aminopeptidases on phagocytosis of immune complexes by macrophages. | Iwaki, S., et al. 1986. J Biochem. 99: 1317-26. PMID: 3711065
Inhibitor of:
Aminopeptidase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Bestatin Methyl Ester, 5 mg | sc-221350 | 5 mg | $218.00 |