Date published: 2025-10-19

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Berteroin (CAS 4430-42-6)

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Alternate Names:
5-Methylthiopentyl isothiocyanate
Application:
Berteroin is which protects against metasticity
CAS Number:
4430-42-6
Purity:
≥97%
Molecular Weight:
175.43
Molecular Formula:
C7H13NS2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Berteroin is a sulforaphane analog found in cruciferous vegetables including Chinese cabbage, rucola salad leaves, and mustard oil. It protects against metastaticity and tumor cell growth. It also reduces the transcription of the androgen receptor and increases the activity of the phase II enzyme quinone reductase. In addition, Berteroin exerts anti-inflammatory activity in LPS-stimulated RAW 264.7 macrophages, inhibiting degradation of IκBα, as well as NF-κB p65 translocation to the nucleus and DNA binding activity. Moreover, it suppresses IRAK degradation and phosphorylation of TAK1, p38 MAPK, ERK1/2, and Akt. Within the cell, Berteroin is primarily located in the membrane (predicted from logP).


Berteroin (CAS 4430-42-6) References

  1. Effects of isothiocyanates on growth and metastaticity of B16-F10 melanoma cells.  |  Sasaki, T., et al. 1999. Nutr Cancer. 33: 76-81. PMID: 10227047
  2. D,L-Sulforaphane causes transcriptional repression of androgen receptor in human prostate cancer cells.  |  Kim, SH. and Singh, SV. 2009. Mol Cancer Ther. 8: 1946-54. PMID: 19584240
  3. Comparison of the apoptosis-inducing capability of sulforaphane analogues in human colon cancer cells.  |  Kim, MJ., et al. 2010. Anticancer Res. 30: 3611-9. PMID: 20944144
  4. Germination stimulants of Phelipanche ramosa in the rhizosphere of Brassica napus are derived from the glucosinolate pathway.  |  Auger, B., et al. 2012. Mol Plant Microbe Interact. 25: 993-1004. PMID: 22414435
  5. Urease from Helicobacter pylori is inactivated by sulforaphane and other isothiocyanates.  |  Fahey, JW., et al. 2013. Biochem Biophys Res Commun. 435: 1-7. PMID: 23583386
  6. Berteroin present in cruciferous vegetables exerts potent anti-inflammatory properties in murine macrophages and mouse skin.  |  Jung, YJ., et al. 2014. Int J Mol Sci. 15: 20686-705. PMID: 25393510
  7. Sulforaphane Inhibits c-Myc-Mediated Prostate Cancer Stem-Like Traits.  |  Vyas, AR., et al. 2016. J Cell Biochem. 117: 2482-95. PMID: 26990292
  8. Berteroin ameliorates lipid accumulation through AMPK-mediated regulation of hepatic lipid metabolism and inhibition of adipocyte differentiation.  |  Kim, YJ., et al. 2021. Life Sci. 282: 119668. PMID: 34087283
  9. Characterization of Conyza bonariensis Allelochemicals against Broomrape Weeds.  |  Peralta, AC., et al. 2022. Molecules. 27: PMID: 36364247
  10. Cruciferous vegetables: prototypic anti-inflammatory food components  |  Tilg, H. 2015. Clinical Phytoscience. 1(1): 1-6.
  11. Postharvest variation of major glucosinolate and their hydrolytic products in Brassicoraphanus 'BB1'  |  Han, N., Ku, K. M., & Kim, J. 2019. Postharvest Biology and Technology. 154: 70-78.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Berteroin, 25 mg

sc-204646
25 mg
$194.00

Berteroin, 50 mg

sc-204646A
50 mg
$337.00

Berteroin, 100 mg

sc-204646B
100 mg
$587.00

Berteroin, 500 mg

sc-204646C
500 mg
$1958.00