Molecular structure of Bergapten, CAS Number: 484-20-8
Bergapten (CAS 484-20-8)
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Alternate Names:
5-Methoxypsoralen; 4-Methoxyfuro[3,2-g]benzopyrane-7-one
Application:
Bergapten is a psoralen phytotoxic citrus essential oil found in bergamont
CAS Number:
484-20-8
Purity:
≥98%
Molecular Weight:
216.19
Molecular Formula:
C12H8O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Bergapten (5-methoxypsoralen) is a psoralen (also known as furocoumarins) found in bergamot essential oil and many other citrus essential oils, and is the chemical in bergamot oil that causes phototoxicity.Bergapten, a naturally occurring furocoumarin found in multiple plants, holds significant potential in biochemistry. Recent extensive studies have revealed both beneficial and detrimental biological activities associated with Bergapten. In scientific research, Bergapten finds broad applications. In vivo, it has been employed to examine the impact of ultraviolet radiation. In vitro, researchers have utilized Bergapten to study the effects of different drugs on cells and the impact of ultraviolet radiation on cellular behavior.
Bergapten (CAS 484-20-8) References
- Bergapten induces ER depletion in breast cancer cells through SMAD4-mediated ubiquitination. | Panno, ML., et al. 2012. Breast Cancer Res Treat. 136: 443-55. PMID: 23053665
- Bergapten induces metabolic reprogramming in breast cancer cells. | Santoro, M., et al. 2016. Oncol Rep. 35: 568-76. PMID: 26459431
- Bergapten induces G1 arrest and pro-apoptotic cascade in colorectal cancer cells associating with p53/p21/PTEN axis. | Lin, CP., et al. 2019. Environ Toxicol. 34: 303-311. PMID: 30576070
- Bergapten alleviates osteoarthritis by regulating the ANP32A/ATM signaling pathway. | He, Y., et al. 2019. FEBS Open Bio. 9: 1144-1152. PMID: 31037830
- Bergapten Ameliorates Vincristine-Induced Peripheral Neuropathy by Inhibition of Inflammatory Cytokines and NFκB Signaling. | Singh, G., et al. 2019. ACS Chem Neurosci. 10: 3008-3017. PMID: 31064179
- Protective effect of bergapten in acetic acid-induced colitis in rats. | Adakudugu, EA., et al. 2020. Heliyon. 6: e04710. PMID: 32885074
- Bergapten Improves Scopolamine-Induced Memory Impairment in Mice via Cholinergic and Antioxidative Mechanisms. | Kowalczyk, J., et al. 2020. Front Neurosci. 14: 730. PMID: 32903765
- Bergapten: A review of its pharmacology, pharmacokinetics, and toxicity. | Liang, Y., et al. 2021. Phytother Res. 35: 6131-6147. PMID: 34347307
- Tadalafil and bergapten mitigate streptozotocin-induced sporadic Alzheimer's disease in mice via modulating neuroinflammation, PI3K/Akt, Wnt/β-catenin, AMPK/mTOR signaling pathways. | Salem, MA., et al. 2021. Toxicol Appl Pharmacol. 429: 115697. PMID: 34428446
- Protective Effect of Bergapten against Human Erythrocyte Hemolysis and Protein Denaturation In Vitro. | Aidoo, DB., et al. 2021. Int J Inflam. 2021: 1279359. PMID: 34970434
- Pharmacological Properties of Bergapten: Mechanistic and Therapeutic Aspects. | Quetglas-Llabrés, MM., et al. 2022. Oxid Med Cell Longev. 2022: 8615242. PMID: 35509838
- Bergapten mediated inflammatory and apoptosis through AMPK/eNOS/AKT signaling pathway of isoproterenol-induced myocardial infarction in Wistar rats. | Yang, Y., et al. 2022. J Biochem Mol Toxicol. 36: e23143. PMID: 35815753
- Bergapten attenuates microglia-mediated neuroinflammation and ischemic brain injury by targeting Kv1.3 and Carbonyl reductase 1. | Gao, S., et al. 2022. Eur J Pharmacol. 933: 175242. PMID: 36058290
- Pharmacological basis of bergapten in gastrointestinal diseases focusing on H+/K+ ATPase and voltage-gated calcium channel inhibition: A toxicological evaluation on vital organs. | Aslam, H., et al. 2022. Front Pharmacol. 13: 1005154. PMID: 36467058
- Bergapten inhibits NLRP3 inflammasome activation and pyroptosis via promoting mitophagy. | Luo, T., et al. 2023. Acta Pharmacol Sin.. PMID: 37142684
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Bergapten, 1 g | sc-207353A | 1 g | $38.00 | |||
Bergapten, 5 g | sc-207353 | 5 g | $125.00 | |||
Bergapten, 25 g | sc-207353B | 25 g | $350.00 | |||
Bergapten, 100 g | sc-207353C | 100 g | $975.00 | |||
Bergapten, 250 g | sc-207353D | 250 g | $2000.00 |