Date published: 2026-4-3

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Berberine hydrochloride (CAS 633-65-8)

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Alternate Names:
Natural Yellow 18; Berberinium chloride; BBR; Umbellatine
Application:
Berberine hydrochloride is an isoquinoline alkaloid
CAS Number:
633-65-8
Purity:
>95%
Molecular Weight:
371.81
Molecular Formula:
C20H17NO4•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Berberine hydrochloride is an alkaloid found in various plants, including goldenseal, barberry, and Oregon grape. Berberine hydrochloride has been studied for its potential effects on various cellular processes, including metabolism, inflammation, and oxidative stress. It interacts with a number of molecular targets, including enzymes and signaling pathways. Berberine hydrochloride has antimicrobial properties. Berberine hydrochloride is a versatile compound with a wide range of biochemical effects.


Berberine hydrochloride (CAS 633-65-8) References

  1. Berberine hydrochloride: anticancer activity and nanoparticulate delivery system.  |  Tan, W., et al. 2011. Int J Nanomedicine. 6: 1773-7. PMID: 21931477
  2. Berberine hydrochloride attenuates lipopolysaccharide-induced endometritis in mice by suppressing activation of NF-κB signal pathway.  |  Fu, K., et al. 2015. Int Immunopharmacol. 24: 128-32. PMID: 25479718
  3. Berberine hydrochloride inhibits cell proliferation and promotes apoptosis of non-small cell lung cancer via the suppression of the MMP2 and Bcl-2/Bax signaling pathways.  |  Li, J., et al. 2018. Oncol Lett. 15: 7409-7414. PMID: 29725453
  4. Protective effects of berberine hydrochloride on DSS-induced ulcerative colitis in rats.  |  Zhu, L., et al. 2019. Int Immunopharmacol. 68: 242-251. PMID: 30743078
  5. Inhibitory Effects of Berberine Hydrochloride on Trichophyton mentagrophytes and the Underlying Mechanisms.  |  Xiao, CW., et al. 2019. Molecules. 24: PMID: 30791402
  6. Inhibition of berberine hydrochloride on Candida albicans biofilm formation.  |  Huang, X., et al. 2020. Biotechnol Lett. 42: 2263-2269. PMID: 32557120
  7. Berberine hydrochloride inhibits inflammation and fibrosis after canalicular laceration repair in rabbits.  |  Bai, F., et al. 2020. Life Sci. 261: 118479. PMID: 32966840
  8. Effects of berberine hydrochloride on methamphetamine-induced anxiety behaviors and relapse in rats.  |  Rezaeian, L., et al. 2020. Iran J Basic Med Sci. 23: 1480-1488. PMID: 33235706
  9. Mechanism of berberine hydrochloride interfering with biofilm formation of Hafnia alvei.  |  Pang, Y., et al. 2022. Arch Microbiol. 204: 126. PMID: 34997845
  10. Hydrochloride Berberine ameliorates alcohol-induced liver injury by regulating inflammation and lipid metabolism.  |  Ke, X., et al. 2022. Biochem Biophys Res Commun. 610: 49-55. PMID: 35436630
  11. Effects of berberine hydrochloride on immune response in the crab Charybdis japonica.  |  Gao, TH., et al. 2022. BMC Genomics. 23: 578. PMID: 35953779
  12. Neuroprotective Effects of Berberine Hydrochloride on Methamphetamine-induced Cognitive Dysfunction: Immunohistochemical and Behavioral Studies in Rats.  |  Rezaeian, L., et al. 2022. Basic Clin Neurosci. 13: 443-453. PMID: 36561238

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Berberine hydrochloride, 1 g

sc-204645
1 g
$41.00

Berberine hydrochloride, 5 g

sc-204645A
5 g
$56.00

Berberine hydrochloride, 25 g

sc-204645B
25 g
$133.00

Berberine hydrochloride, 100 g

sc-204645C
100 g
$374.00

Berberine hydrochloride, 500 g

sc-204645D
500 g
$1321.00

The COA indicates that the product name is berberine chloride, but there is no indication of hydrate. Is this material itself dried? Is it a dry substance that does not require a separate moisture measurement to be considered anhydrous?(sc-204645A)

Asked by: happy
Thank you for your question. Berberine chloride is the hydrochloride salt of berberine. Berberine hydrochloride and berberine chloride are synonyms.
Answered by: Technical Service SH
Date published: 2024-04-07

Come conservare una soluzione 1mM di Berberine hydrochloride sc-204645B preparata in acqua bidistillata sterile? Devo filtrare la soluzione prima di utilizzarla su linee cellulari? Grazie

Asked by: Ale75
Thank you for your question. We recommend storing the compound as a solid and preparing solutions as required. As supplied, Berberine hydrochloride is not sterile, so filtration would be advised prior to use in cell culture.
Answered by: Tech Support Europe
Date published: 2024-03-28
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Date published: 2015-04-20
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Berberine hydrochloride is rated 4.0 out of 5 by 1.
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