Date published: 2025-10-14

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Benzyl butyl phthalate (CAS 85-68-7)

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CAS Number:
85-68-7
Purity:
≥97%
Molecular Weight:
312.36
Molecular Formula:
C19H20O4
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Benzyl butyl phthalate (BBP) is used in a variety of industrial and consumer products, such as plasticizers, lubricants, and adhesives. Benzyl butyl phthalate is also used in the manufacture of plastics and other synthetic materials. In addition, Benzyl butyl phthalate binds to estrogen receptors and can interfere with the normal functioning of these receptors. This can lead to a variety of biological effects, including changes in gene expression, endocrine disruption, and reproductive toxicity. Benzyl butyl phthalate may act to be a potent mutagen in cell cultures. It has also been reported to have an inhibitory effect on the activity of certain enzymes, such as cytochrome P450 enzymes.


Benzyl butyl phthalate (CAS 85-68-7) References

  1. Benzyl butyl phthalate induces necrosis by AhR mediation of CYP1B1 expression in human granulosa cells.  |  Chen, HS., et al. 2012. Reprod Toxicol. 33: 67-75. PMID: 22138065
  2. Benzyl butyl phthalate exposure impairs learning and memory and attenuates neurotransmission and CREB phosphorylation in mice.  |  Min, A., et al. 2014. Food Chem Toxicol. 71: 81-9. PMID: 24937021
  3. Benzyl butyl phthalate induces migration, invasion, and angiogenesis of Huh7 hepatocellular carcinoma cells through nongenomic AhR/G-protein signaling.  |  Tsai, CF., et al. 2014. BMC Cancer. 14: 556. PMID: 25081364
  4. Benzyl butyl phthalate increases the chemoresistance to doxorubicin/cyclophosphamide by increasing breast cancer-associated dendritic cell-derived CXCL1/GROα and S100A8/A9.  |  Hsu, YL., et al. 2015. Oncol Rep. 34: 2889-900. PMID: 26397389
  5. Benzyl butyl phthalate promotes adipogenesis in 3T3-L1 preadipocytes: A High Content Cellomics and metabolomic analysis.  |  Yin, L., et al. 2016. Toxicol In Vitro. 32: 297-309. PMID: 26820058
  6. Benzyl butyl phthalate promotes breast cancer stem cell expansion via SPHK1/S1P/S1PR3 signaling.  |  Wang, YC., et al. 2016. Oncotarget. 7: 29563-76. PMID: 27129165
  7. Benzyl butyl phthalate induces epigenetic stress to enhance adipogenesis in mesenchymal stem cells.  |  Sonkar, R., et al. 2016. Mol Cell Endocrinol. 431: 109-22. PMID: 27164441
  8. Benzyl butyl phthalate (BBP) triggers the migration and invasion of hemangioma cells via upregulation of Zeb1.  |  Cui, S., et al. 2019. Toxicol In Vitro. 60: 323-329. PMID: 31212022
  9. Benzyl butyl phthalate non-linearly affects rat Leydig cell development during puberty.  |  Lv, Y., et al. 2019. Toxicol Lett. 314: 53-62. PMID: 31319113
  10. Benzyl butyl phthalate (BBP) triggers the malignancy of acute myeloid leukemia cells via upregulation of PDK4.  |  Duan, XL., et al. 2020. Toxicol In Vitro. 62: 104693. PMID: 31629899
  11. Benzyl Butyl Phthalate Induced Early lncRNA H19 Regulation in C3H10T1/2 Stem Cell Line.  |  Zhang, J. and Choudhury, M. 2021. Chem Res Toxicol. 34: 54-62. PMID: 33395283
  12. Benzyl butyl phthalate activates prophage, threatening the stable operation of waste activated sludge anaerobic digestion.  |  Tang, X., et al. 2021. Sci Total Environ. 768: 144470. PMID: 33454470
  13. Biodegradation of endocrine disrupting chemicals benzyl butyl phthalate and dimethyl phthalate by Bacillus marisflavi RR014.  |  Kaur, R., et al. 2021. J Appl Microbiol. 131: 1274-1288. PMID: 33599367
  14. Pyrroloquinoline quinone attenuated benzyl butyl phthalate induced metabolic aberration and a hepatic metabolomic analysis.  |  Zhang, J., et al. 2022. Biochem Pharmacol. 197: 114883. PMID: 34971587
  15. Benzyl butyl phthalate (BBP) induces lung injury and fibrosis through neutrophil extracellular traps.  |  Wang, W., et al. 2022. Environ Pollut. 309: 119743. PMID: 35835272

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Benzyl butyl phthalate, 5 ml

sc-239317
5 ml
$61.00

Benzyl butyl phthalate, 250 ml

sc-239317A
250 ml
$77.00

Benzyl butyl phthalate, 1 L

sc-239317B
1 L
$204.00