Benzydamine N-Oxide (CAS 36504-71-9)
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Benzydamine N-oxide, a derivative of benzydamine, operates through a unique mechanism as an oxidized form of its parent compound. It is primarily investigated for its potential in various research domains, particularly for its distinctive chemical properties and interactions with biological molecules. The compound′s mechanism of action is thought to involve the modulation of oxidative stress pathways and the alteration of signaling mechanisms within cells, though its precise biochemical interactions are subject to ongoing research. Unlike benzydamine, which has been extensively studied for its anti-inflammatory properties, benzydamine N-oxide′s role in research is geared more towards understanding the implications of N-oxidation on pharmacokinetics and the molecular dynamics of related compounds. Its study contributes to a broader comprehension of how structural modifications can impact the activity and selectivity of molecules, offering insights into the design of novel compounds with specific biological actions.
Benzydamine N-Oxide (CAS 36504-71-9) References
- Estimation of flavin-containing monooxygenase activity in intact hepatocyte monolayers of rat, hamster, rabbit, dog and human by using N-oxidation of benzydamine. | Ubeaud, G., et al. 1999. Eur J Pharm Sci. 8: 255-60. PMID: 10425375
- In vitro evaluation of potential in vivo probes for human flavin-containing monooxygenase (FMO): metabolism of benzydamine and caffeine by FMO and P450 isoforms. | Lang, DH. and Rettie, AE. 2000. Br J Clin Pharmacol. 50: 311-4. PMID: 11012553
- Benzydamine N-oxidation as an index reaction reflecting FMO activity in human liver microsomes and impact of FMO3 polymorphisms on enzyme activity. | Störmer, E., et al. 2000. Br J Clin Pharmacol. 50: 553-61. PMID: 11136294
- Biotransformation of benzydamine by microsomes and precision-cut slices prepared from cattle liver. | Santi, A., et al. 2002. Xenobiotica. 32: 73-86. PMID: 11820511
- Benzydamine N-oxygenation as a measure of flavin-containing monooxygenase activity. | Yeung, CK. and Rettie, AE. 2006. Methods Mol Biol. 320: 157-62. PMID: 16719388
- Determination of benzydamine and its N-oxide in biological fluids by high-performance liquid chromatography. | Baldock, GA., et al. 1990. J Chromatogr. 529: 113-23. PMID: 2211924
- Benzydamine N-oxygenation as an index for flavin-containing monooxygenase activity and benzydamine N-demethylation by cytochrome P450 enzymes in liver microsomes from rats, dogs, monkeys, and humans. | Taniguchi-Takizawa, T., et al. 2015. Drug Metab Pharmacokinet. 30: 64-9. PMID: 25760531
- Human plasma metabolic profiles of benzydamine, a flavin-containing monooxygenase probe substrate, simulated with pharmacokinetic data from control and humanized-liver mice. | Yamazaki-Nishioka, M., et al. 2018. Xenobiotica. 48: 117-123. PMID: 28145791
- Drug metabolite synthesis by immobilized human FMO3 and whole cell catalysts. | Gao, C. and Zheng, T. 2019. Microb Cell Fact. 18: 133. PMID: 31405378
- In vivo metabolism and anti-inflammatory activity of benzydamine hydrochloride in rats treated with carrageenin. | Kataoka, S., et al. 1979. Chem Pharm Bull (Tokyo). 27: 2890-903. PMID: 540330
- Effect of carrageenin treatment on the metabolism of benzydamine and its N-oxide in rat organ preparations. | Kataoka, S., et al. 1979. Chem Pharm Bull (Tokyo). 27: 2904-12. PMID: 540331
- Reduction of benzydamine N-oxide by rat liver xanthine oxidase. | Kataoka, S. and Naito, T. 1979. Chem Pharm Bull (Tokyo). 27: 2913-20. PMID: 583461
- Flavin-containing monooxygenase mediated metabolism of benzydamine in perfused brain and liver. | Kawaji, A., et al. 1998. Biochim Biophys Acta. 1425: 41-6. PMID: 9813235
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Benzydamine N-Oxide, 5 mg | sc-207328 | 5 mg | $353.00 | |||
Benzydamine N-Oxide, 10 mg | sc-207328A | 10 mg | $633.00 | |||
Benzydamine N-Oxide, 25 mg | sc-207328C | 25 mg | $1475.00 | |||
Benzydamine N-Oxide, 50 mg | sc-207328D | 50 mg | $2454.00 |