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Benzthiazide (CAS 91-33-8)

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Application:
Benzthiazide is a diuretic and antihypertensive compound
CAS Number:
91-33-8
Molecular Weight:
431.94
Molecular Formula:
C15H14ClN3O4S3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Benzthiazide is a diuretic compound that functions by inhibiting the reabsorption of sodium and chloride ions in the distal convoluted tubules of the kidneys. This action prevents the reabsorption of water, leading to increased urine production and subsequent reduction in extracellular fluid volume. The compound achieves this by blocking the action of the sodium-chloride symporter, a transporter protein responsible for the reabsorption of sodium and chloride ions from the urine. By interfering with this process, Benzthiazide promotes the excretion of these ions, ultimately leading to a decrease in blood volume and blood pressure. This mechanism of action makes Benzthiazide useful for studying the regulation of fluid and electrolyte balance in experimental models, providing insights into the physiological processes involved in maintaining homeostasis.


Benzthiazide (CAS 91-33-8) References

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  2. Determination and characterization of diuretics in human urine by liquid chromatography coupled to pneumatically assisted electrospray ionization mass spectrometry.  |  Sanz-Nebot, V., et al. 2001. J Mass Spectrom. 36: 652-7. PMID: 11433538
  3. The antihypertensive effects of chlorthalidone. A comparative analysis with benzothiazide compounds.  |  BRYANT, JM., et al. 1962. Circulation. 25: 522-32. PMID: 13874133
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  5. Effects of pH and the presence of micelles on the resolution of diuretics by reversed-phase liquid chromatography.  |  Ruiz-Angel, MJ., et al. 2004. J Chromatogr A. 1022: 51-65. PMID: 14753771
  6. Combined effect of solvent content, temperature and pH on the chromatographic behaviour of ionisable compounds.  |  Pous-Torres, S., et al. 2007. J Chromatogr A. 1163: 49-62. PMID: 17585924
  7. Application of p-N,N-dimethylphenylenediamine dihydrochloride for the determination of some diuretics.  |  Sastry, CS., et al. 1989. Talanta. 36: 491-4. PMID: 18964744
  8. Rational drug repositioning guided by an integrated pharmacological network of protein, disease and drug.  |  Lee, HS., et al. 2012. BMC Syst Biol. 6: 80. PMID: 22748168
  9. Candidates for Repurposing as Anti-Virulence Agents Based on the Structural Profile Analysis of Microbial Collagenase Inhibitors.  |  Nitulescu, G., et al. 2021. Pharmaceutics. 14: PMID: 35056958
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  12. Inhibition of thiazide photohemolysis in vitro by antioxidants and a nitrogen atmosphere.  |  Selvaag, E. 1996. Photodermatol Photoimmunol Photomed. 12: 211-5. PMID: 9112280
  13. Evaluation of phototoxic properties of oral antidiabetics and diuretics. Photohemolysis model as a screening method for recognizing potential photosensitizing drugs.  |  Selvaag, E. 1997. Arzneimittelforschung. 47: 1031-4. PMID: 9342417

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Benzthiazide, 1 g

sc-233976
1 g
$42.00