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Molecular structure of Benzo[e]pyrene, CAS Number: 192-97-2
Benzo[e]pyrene (CAS 192-97-2)
CAS Number:
192-97-2
Molecular Weight:
252.31
Molecular Formula:
C20H12
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Benzo[e]pyrene, also known as B(e)P, is a highly toxic member of a family of compounds called polyaromatic hydrocarbons (PAHs). It is a pentacyclic aromatic hydrocarbon contaminant and a structural isomer of the potent carcinogen benzo[a]pyrene. Found in the environment, particularly in industrially active areas, it is a significant component of air pollution. Benzo[e]pyrene is present in tobacco smoke. Metabolized in the body, it generates reactive metabolites that interact with DNA and other cellular components, causing mutations and cellular changes. Additionally, Benzo[e]pyrene is believed to induce oxidative stress and inflammation, further damaging cellular components.
Benzo[e]pyrene (CAS 192-97-2) References
- Effects of benzo(e)pyrene and benzo(a)pyrene on P-glycoprotein-mediated transport in Caco-2 cell monolayer: a comparative approach. | Sugihara, N., et al. 2007. Toxicol In Vitro. 21: 827-34. PMID: 17408918
- Benzo[e]pyrene pretreatment of immature, female C57BL/6J mice results in increased bioactivation of aflatoxin B1 in vitro. | Ma, XF., et al. 1991. Toxicol Lett. 59: 51-8. PMID: 1755035
- Co-metabolic degradation of benzo(e)pyrene by halophilic bacterial consortium at different saline conditions. | Arulazhagan, P., et al. 2014. J Environ Biol. 35: 445-52. PMID: 24812998
- Effects of Benzo(e)pyrene on Reactive Oxygen/Nitrogen Species and Inflammatory Cytokines Induction in Human RPE Cells and Attenuation by Mitochondrial-involved Mechanism. | Estrago-Franco, MF., et al. 2016. J Ophthalmic Vis Res. 11: 385-393. PMID: 27994808
- Benzo(e)pyrene Inhibits Endothelium-Dependent NO-Mediated Dilation of Retinal Arterioles via Superoxide Production and Endoplasmic Reticulum Stress. | Kamiya, T., et al. 2017. Invest Ophthalmol Vis Sci. 58: 5978-5984. PMID: 29183043
- Protective Effects of 17β-Estradiol on Benzo(e) pyrene[B(e)P]-induced Toxicity in ARPE-19 cells. | Sapkal, AU., et al. 2018. J Ophthalmic Vis Res. 13: 419-425. PMID: 30479711
- Benzo(e)pyrene-induced alterations in the binding of benzo(a)pyrene and 7,12-dimethylbenz(a)anthracene to DNA in Sencar mouse epidermis. | Smolarek, TA., et al. 1987. Cancer Res. 47: 3701-6. PMID: 3109730
- Benzo[A]Pyrene and Benzo[E]Pyrene: Photoreactivity and Phototoxicity toward Human Keratinocytes. | Mokrzyński, K., et al. 2022. Photochem Photobiol.. PMID: 36117444
- Benzo[e]pyrene-induced alterations in the binding of benzo[a]pyrene to DNA in hamster embryo cell cultures. | Smolarek, TA. and Baird, WM. 1984. Carcinogenesis. 5: 1065-9. PMID: 6086168
- Anticarcinogenic and cocarcinogenic effects of benzo[e]pyrene and dibenz[a,c]anthracene on skin tumor initiation by polycyclic hydrocarbons. | DiGiovanni, J., et al. 1982. Carcinogenesis. 3: 371-5. PMID: 6284398
- Benzo(e)pyrene-induced alterations in the metabolic activation of benzo(a)pyrene and 7,12-dimethylbenz(a)anthracene by hamster embryo cells. | Baird, WM., et al. 1984. Cancer Res. 44: 1445-52. PMID: 6322978
- Benzo[e]pyrene metabolism in rat liver microsomes: dependence of the metabolite profile on the pretreatment of rats with various monooxygenase inducers. | Jacob, J., et al. 1983. Carcinogenesis. 4: 905-10. PMID: 6872145
- Tumorigenic activity of benzo(e)pyrene derivatives on mouse skin and in newborn mice. | Buening, MK., et al. 1980. Cancer Res. 40: 203-6. PMID: 7356502
Inhibitor of:
polycyclic aromatic hydrocarbons.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Benzo[e]pyrene, 25 mg | sc-257135 | 25 mg | $541.00 |