Benzo[a]pyrene Antibody (BAP-13): sc-51508

Benzo[a]pyrene Antibody (BAP-13) is a mouse monoclonal IgG1 antibody that detects Benzo[a]pyrene protein by immunofluorescence (IF). Anti-Benzo[a]pyrene antibody (BAP-13) is available as a non-conjugated antibody, specifically designed to facilitate the study of this potent environmental contaminant. Benzo[a]pyrene is a five-ring polycyclic aromatic hydrocarbon that is not only mutagenic but also highly carcinogenic, making it a significant concern in environmental health and toxicology. This compound is primarily formed through incomplete combustion processes, occurring at temperatures between 300 and 600°C, and is commonly found in coal tar, automobile exhaust (particularly from diesel engines), tobacco smoke, and charbroiled foods. Understanding the structure of Benzo[a]pyrene is crucial, as its planar configuration allows for intercalation into DNA, leading to mutations that can initiate carcinogenesis. The ability of Benzo[a]pyrene to form adducts with DNA is a key factor in its role as a carcinogen, highlighting the importance of studying this protein in various biological contexts. Anti-Benzo[a]pyrene antibody (BAP-13) can be used to explore the mechanisms of toxicity and the biological effects of exposure to this hazardous compound, thereby contributing to the development of strategies for risk assessment and mitigation in public health.

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Benzo[a]pyrene Antibody (BAP-13) References:

1. Monoclonal antibodies specific to polynuclear aromatic hydrocarbons.  |  Suchánek, M., et al. 2001. Folia Biol (Praha). 47: 106-7. PMID: 11409316
2. Monoclonal antibody to polycyclic aromatic hydrocarbons based on a new benzo[a]pyrene immunogen.  |  Scharnweber, T., et al. 2001. Fresenius J Anal Chem. 371: 578-85. PMID: 11767882
3. Synthesis and cytotoxic activity of benzo[a]pyrano[3,2-h] and [2,3-i]xanthone analogues of psorospermine, acronycine, and benzo[a]acronycine.  |  Sittisombut, C., et al. 2006. Chem Pharm Bull (Tokyo). 54: 1113-8. PMID: 16880654
4. Benzo(a)pyrene inhibits expression of inducible heat shock protein 70 in vascular endothelial cells.  |  Gong, Z., et al. 2006. Toxicol Lett. 166: 229-36. PMID: 16962263
5. Temporal changes of ethoxyresorufin-o-deethylase (EROD) activities and lysosome accumulation in intestine of fish on chronic exposure to dietary benzo[a]pyrene: linking erod induction to cytological effects.  |  Yuen, BB. and Au, DW. 2006. Environ Toxicol Chem. 25: 2593-600. PMID: 17022398
6. Benzo[a]pyrene-induced DNA damage and p53 modulation in human hepatoma HepG2 cells for the identification of potential biomarkers for PAH monitoring and risk assessment.  |  Park, SY., et al. 2006. Toxicol Lett. 167: 27-33. PMID: 17029827
7. Time- and concentration-dependent changes in gene expression induced by benzo(a)pyrene in two human cell lines, MCF-7 and HepG2.  |  Hockley, SL., et al. 2006. BMC Genomics. 7: 260. PMID: 17042939
8. Determination of 3,6-dinitrobenzo[e]pyrene in surface soil and airborne particles by high-performance liquid chromatography with fluorescence detection.  |  Hasei, T., et al. 2006. J Chromatogr A. 1135: 65-70. PMID: 17045278
9. Quantitative analysis of benzo[a]pyrene biotransformation and adduct formation in Ahr knockout mice.  |  Sagredo, C., et al. 2006. Toxicol Lett. 167: 173-82. PMID: 17049425

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Benzo[a]pyrene Antibody (BAP-13) has 6 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Benzo[a]pyrene Antibody (BAP-13) Specifications

Alternate Product Name: Benzo[a]pyrene

Product Clone Name: BAP-13

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: Benzo[a]pyrene

Epitope Species: n/a

Product Reactivity/Detection: DNA and protein adducts of Benzo[a]pyrene

Species Reactivity/Detection: N/A

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: IF

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 6 citations in various scientific publications

Available Conjugates/Forms for Benzo[a]pyrene Antibody (BAP-13): N/A