![Benzo[a]pyrene (CAS 50-32-8) - chemical structure image](https://media.scbt.com/product/benzoapyrene-50-32-8-structure_11_34_b_113414.jpg)
![Benzo[a]pyrene (CAS 50-32-8) - chemical structure image](https://media.scbt.com/product/benzoapyrene-50-32-8-structure_11_34_t_113414.jpg "Molecular structure of Benzo[a]pyrene, CAS Number: 50-32-8")
Molecular structure of Benzo[a]pyrene, CAS Number: 50-32-8
Benzo[a]pyrene (CAS 50-32-8)
See product citations (4)
Alternate Names:
3,4-Benzopyrene
Application:
Benzo[a]pyrene is a polycyclic aromatic hydrocarbon
CAS Number:
50-32-8
Purity:
≥95%
Molecular Weight:
252.31
Molecular Formula:
C20H12
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Benzo[a]pyrene is a polycyclic aromatic hydrocarbon (PAH), environmental pollutant and carcinogen. IT is employed as a chemical carcinogen in experimental models of cancer. Carcinogenesis depends on its oxidation by CYP1A1 to benzo[a]pyrenediolepoxide, that forms depurinating adducts with DNA that dissociate to form abasic lesions. Benzo[a]pyrene is a ligand for the arylhydrocarbon receptor (AhR), and some of its biological effects, including the induction of CYP1A1, appear to be mediated via activation of the AhR.
Benzo[a]pyrene (CAS 50-32-8) References
- Resveratrol, a natural aryl hydrocarbon receptor antagonist, protects lung from DNA damage and apoptosis caused by benzo[a]pyrene. | Revel, A., et al. 2003. J Appl Toxicol. 23: 255-61. PMID: 12884409
- Human CYP1A1GFP expression in transgenic mice serves as a biomarker for environmental toxicant exposure. | Operaña, TN., et al. 2007. Toxicol Sci. 95: 98-107. PMID: 17065433
- The aryl hydrocarbon receptor-dependent deregulation of cell cycle control induced by polycyclic aromatic hydrocarbons in rat liver epithelial cells. | Andrysík, Z., et al. 2007. Mutat Res. 615: 87-97. PMID: 17141280
- Enhanced degradation of benzo[a]pyrene and toxicity reduction by microbubble ozonation. | Nam, G., et al. 2021. Environ Technol. 42: 1853-1860. PMID: 31625815
- Interacting mechanism of benzo(a)pyrene with free DNA in vitro. | Xiong, Y., et al. 2021. Int J Biol Macromol. 167: 854-861. PMID: 33181208
- Benzo[a]pyrene aggravates atopic dermatitis-like skin lesions in mice. | Yanagisawa, R., et al. 2021. Hum Exp Toxicol. 40: S269-S277. PMID: 34424081
- Effects of benzo(a)pyrene on meiobenthic assemblage and biochemical biomarkers in an Oncholaimus campylocercoides (Nematoda) microcosm. | Hedfi, A., et al. 2022. Environ Sci Pollut Res Int. 29: 16529-16548. PMID: 34651273
- A new perspective on the benzo(a)pyrene generated in tea seeds during roasting. | Liu, G., et al. 2022. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 39: 440-450. PMID: 35104194
- Enhanced transformation capability towards benzo(a)pyrene by Fe(III)-modified manganese oxides. | Cheng, P., et al. 2022. J Hazard Mater. 431: 128637. PMID: 35278963
- Effects of benzo[a]pyrene exposure on oxidative stress and apoptosis of gill cells of Chlamys farreri in vitro. | Tang, J., et al. 2022. Environ Toxicol Pharmacol. 93: 103867. PMID: 35483583
- Oxidization of benzo[a]pyrene by CYP102 in a novel PAHs-degrader Pontibacillus sp. HN14 with potential application in high salinity environment. | Qian, Z., et al. 2022. J Environ Manage. 321: 115922. PMID: 36027730
- Kinetics of Benzo(a)pyrene biodegradation and bacterial growth in sandy soil by Sphingobacterium spiritovorum. | Alias, S., et al. 2022. Heliyon. 8: e10799. PMID: 36217485
- Butyrate Enhances γ-H2AX Induced by Benzo[a]pyrene. | Tanaka, M., et al. 2022. Chem Res Toxicol. 35: 2241-2251. PMID: 36399157
- The effect of melatonin on benzo(a)pyrene-induced renal toxicity in mice. | Barangi, S., et al. 2023. Toxicol Ind Health. 7482337231166491. PMID: 37022282
- Mechanism of benzo[a]pyrene diol epoxide induced deoxyribonucleic acid strand scission. | Gamper, HB., et al. 1980. Biochemistry. 19: 3948-56. PMID: 6250579
Inhibitor of:
βB2-crystallin, CES3, KRTAP16-5, MMS19, NQO1, OGG2, Osteoglycin, polycyclic aromatic hydrocarbons, RDH7, RDH9, RP23-221K3.2, and UGT1A7.Activator of:
4931417G12Rik, 8-OHdG, AKR7A2, ALKB, Ape2, Arnt 1, Arnt 2, B-Myb, BLM hydrolase, C11orf82, CCL12, Colorectal Adenocarcinoma Marker, Csprs, cyclin δ-3, CYP1A1, CYP1B1, Cyp3a59, CYP4V3, DDB2, DEM1, Dermcidin, Dmc1, DNA Ligase IV, Elastase-2B, FLJ20433, GPBP1L1, Histone H2A.J, HMG-2, IL-3β, IL-8RB, Ku, LOC100039850, LOC100040448, LOC283585, MRP-S14, MT16 kDa antigen, MYH10, NF-1B, NFRκB, NGAL, NTH1, OATP-C, OR7A17, PCB, PGBD3, POL H, POLDIP2, Rad23, Rad5, Rad52, Reg lllγ, Rev3, RMI1, RPA 34 kDa subunit, Su, TFIIH 2C, UDG, UGT1A1, UGT1A5, UGT1A6A, UGT1A6B, UGT2A2, UGT2B10, UGT2B11, UGT2B28, UGT2B4, VACVase, and XPV.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Benzo[a]pyrene, 1 g | sc-257130 | 1 g | $612.00 |