Molecular structure of Benzisoxazole Hsp90 Inhibitor, CAS Number: 1012788-65-6
Benzisoxazole Hsp90 Inhibitor (CAS 1012788-65-6)
Alternate Names:
4-chloro-6-[5-[[2-(4-morpholinyl)ethyl]amino]-1,2-benzisoxazol-3-yl]-1,3-benzenediol
Application:
Benzisoxazole Hsp90 Inhibitor is an inhibitor that binds to the N-terminal domain of Hsp90
CAS Number:
1012788-65-6
Purity:
≥98%
Molecular Weight:
389.84
Molecular Formula:
C19H20ClN3O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Heat shock protein 90 (Hsp90) is a molecular chaperone that modulates intracellular signaling and protein folding, trafficking, and turnover. Inhibitors of Hsp90, such as geldanamycin, have shown potential as anti-tumor agents. Benzisoxazole Hsp90 Inhibitor binds the N-terminal domain of Hsp90, efficiently displacing geldanamycin from the ATP binding site (IC50 = 30 nM) (1). It also inhibits the proliferation of several cancer cell lines (IC50 ~ 0.28 μM), promotes the degradation of the Hsp90 client proteins Her-2 and androgen receptor, and has no effect on a variety of kinases (1).
Inhibitor of:
HSP 90.Activator of:
ZFAND2A.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Benzisoxazole Hsp90 Inhibitor, 1 mg | sc-223790 | 1 mg | $196.00 | |||
Benzisoxazole Hsp90 Inhibitor, 5 mg | sc-223790A | 5 mg | $885.00 |