Molecular structure of Benzimidazole, CAS Number: 51-17-2
Benzimidazole (CAS 51-17-2)
Alternate Names:
1,3-Benzodiazole, BZI
CAS Number:
51-17-2
Molecular Weight:
118.14
Molecular Formula:
C7H6N2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Benzimidazole is a heterocyclic organic compound and an important building block in the synthesis of many biologically active compounds. It has been found to inhibit the activity of certain enzymes involved in drug metabolism, and to act as an antagonist of certain receptors, such as the 5-HT2A receptor, which is involved in the regulation of mood and behavior. It also has anti-inflammatory, anti-cancer, and anti-oxidant activities. It has been used to study the effects of various drugs on cell cultures, to assess the efficacy of drugs in treating various diseases, and to study the effects of environmental chemicals on cell cultures.
Benzimidazole (CAS 51-17-2) References
- Benzimidazole treatment of cystic echinococcosis. | El-On, J. 2003. Acta Trop. 85: 243-52. PMID: 12606103
- Synthetic thioamide, benzimidazole, quinolone and derivatives with carboxylic acid and ester moieties: a strategy in the design of antituberculosis agents. | Ashfaq, M., et al. 2014. Curr Med Chem. 21: 911-31. PMID: 24164193
- Comprehensive Review in Current Developments of Benzimidazole-Based Medicinal Chemistry. | Keri, RS., et al. 2015. Chem Biol Drug Des. 86: 19-65. PMID: 25352112
- Structure activity relationship (SAR) study of benzimidazole scaffold for different biological activities: A mini-review. | Yadav, G. and Ganguly, S. 2015. Eur J Med Chem. 97: 419-43. PMID: 25479684
- Some characteristics of activity of potential chemotherapeutics--benzimidazole derivatives. | Błaszczak-Świątkiewicz, K. and Mikiciuk-Olasik, E. 2015. Adv Med Sci. 60: 125-32. PMID: 25725479
- Perspectives of Benzimidazole Derivatives as Anticancer Agents in the New Era. | Yadav, S., et al. 2016. Anticancer Agents Med Chem. 16: 1403-1425. PMID: 26526461
- Benzimidazole Scaffold as Anticancer Agent: Synthetic Approaches and Structure-Activity Relationship. | Shrivastava, N., et al. 2017. Arch Pharm (Weinheim). 350: PMID: 28544162
- Investigation of the toxicological and inhibitory effects of some benzimidazole agents on acetylcholinesterase and butyrylcholinesterase enzymes. | Türkan, F. 2021. Arch Physiol Biochem. 127: 97-101. PMID: 31135232
- Benzimidazole inhibitors of the major cysteine protease of Trypanosoma brucei. | Pereira, GA., et al. 2019. Future Med Chem. 11: 1537-1551. PMID: 31469332
- Benzimidazole Derivative Ameliorates Opioid-Mediated Tolerance during Anticancer- Induced Neuropathic Pain in Mice. | Akhtar, S., et al. 2021. Anticancer Agents Med Chem. 21: 365-371. PMID: 32819235
- Recent Advancements on Benzimidazole: A Versatile Scaffold in Medicinal Chemistry. | Alzhrani, ZMM., et al. 2022. Mini Rev Med Chem. 22: 365-386. PMID: 33797365
- Clinical Efficacy and Safety of Albendazole and Other Benzimidazole Anthelmintics for Rat Lungworm Disease (Neuroangiostrongyliasis): A Systematic Analysis of Clinical Reports and Animal Studies. | Jacob, J., et al. 2022. Clin Infect Dis. 74: 1293-1302. PMID: 34448480
- Recent progress of research on anti-tumor agents using benzimidazole as the structure unit. | Wu, K., et al. 2022. Chem Biol Drug Des. 99: 736-757. PMID: 35064629
- Identification of key interactions of benzimidazole resistance-associated amino acid mutations in Ascaris β-tubulins by molecular docking simulations. | Jones, BP., et al. 2022. Sci Rep. 12: 13725. PMID: 35961997
- Benzimidazole-based protein kinase inhibitors: Current perspectives in targeted cancer therapy. | Ali, AM., et al. 2022. Chem Biol Drug Des. 100: 656-673. PMID: 35962624
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HNF-1β.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Benzimidazole, 50 g | sc-280611 | 50 g | $63.00 | |||
Benzimidazole, 250 g | sc-280611A | 250 g | $236.00 | |||
Benzimidazole, 500 g | sc-280611B | 500 g | $316.00 | |||
Benzimidazole, 1 kg | sc-280611C | 1 kg | $367.00 | |||
Benzimidazole, 5 kg | sc-280611D | 5 kg | $520.00 |