Molecular structure of Benzamidine Hydrochloride, Anhydrous, CAS Number: 1670-14-0
Benzamidine Hydrochloride, Anhydrous (CAS 1670-14-0)
See product citations (11)
Alternate Names:
Amidinobenzene hydrochloride
Application:
Benzamidine Hydrochloride, Anhydrous is a serine protease enzyme inhibitor
CAS Number:
1670-14-0
Purity:
≥97%
Molecular Weight:
156.61
Molecular Formula:
C7H8N2•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Benzamidine and its derivatives serve as inhibitors of serine protease enzymes, namely tryptase, thrombin, and tripsin-like enzymes. The strong affinity of benzamidine for these enzymes has been exploited to crystallize and study spectra of thrombin complexes. Benzamidine inhibits the autoactivation of human blood coagulation factor VII, useful as a tool for studying the interactions between this and other relevant growth factors. A derivative of this compound has shown activity against the growth of colon cancer cells.
Benzamidine Hydrochloride, Anhydrous (CAS 1670-14-0) References
- A serine protease-inhibitory benzamidine derivative inhibits the growth of human colon carcinoma cells. | Nishimura, Y., et al. 1992. Jpn J Cancer Res. 83: 723-8. PMID: 1517149
- Refined 2.3 A X-ray crystal structure of bovine thrombin complexes formed with the benzamidine and arginine-based thrombin inhibitors NAPAP, 4-TAPAP and MQPA. A starting point for improving antithrombotics. | Brandstetter, H., et al. 1992. J Mol Biol. 226: 1085-99. PMID: 1518046
- Tissue factor-dependent autoactivation of human blood coagulation factor VII. | Yamamoto, M., et al. 1992. J Biol Chem. 267: 19089-94. PMID: 1527033
- Complete Kinetic Characterization of Enzyme Inhibition in a Single Isothermal Titration Calorimetric Experiment. | Di Trani, JM., et al. 2018. Anal Chem. 90: 8430-8435. PMID: 29926719
- Mammalian tissue trypsin-like enzymes: substrate specificity and inhibitory potency of substituted isocoumarin mechanism-based inhibitors, benzamidine derivatives, and arginine fluoroalkyl ketone transition-state inhibitors. | Kam, CM., et al. 1995. Arch Biochem Biophys. 316: 808-14. PMID: 7864637
Inhibitor of:
KLK11, Protease, Thrombin, Trypsin, and Tryptase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Benzamidine Hydrochloride, Anhydrous, 5 g | sc-202973 | 5 g | $44.00 | |||
Benzamidine Hydrochloride, Anhydrous, 25 g | sc-202973A | 25 g | $148.00 | |||
Benzamidine Hydrochloride, Anhydrous, 100 g | sc-202973B | 100 g | $260.00 | |||
Benzamidine Hydrochloride, Anhydrous, 250 g | sc-202973C | 250 g | $364.00 | |||
Benzamidine Hydrochloride, Anhydrous, 1 kg | sc-202973D | 1 kg | $832.00 | |||
Benzamidine Hydrochloride, Anhydrous, 5 kg | sc-202973E | 5 kg | $3329.00 |