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Benserazide·HCl (Ro 4-4602) (CAS 14919-77-8)

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Alternate Names:
DL-Serine 2-(2,3,4-trihydroxybenzyl)hydrazide hydrochloride
Application:
Benserazide⋅HCl (Ro 4-4602) is an aromatic L-aminoacid decarboxylase inhibitor
CAS Number:
14919-77-8
Purity:
≥99%
Molecular Weight:
293.74
Molecular Formula:
C10H15N3O5•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Benserazide·HCl (Ro 4-4602) is a compound that is extensively used in biochemical research, particularly in studies concerning amino acid decarboxylation. This compound serves as an inhibitor of aromatic L-amino acid decarboxylase (AAAD), an enzyme responsible for the decarboxylation of L-DOPA to dopamine. By inhibiting this enzyme, Benserazide·HCl (Ro 4-4602) is instrumental in research that investigates the metabolism and regulation of neurotransmitter precursors. The hydrochloride salt form of this compound improves its solubility in aqueous solutions, facilitating its use in various experimental setups, including in vitro enzyme assays. Additionally, benserazide hydrochloride is utilized in studies examining the transport of amino acids across the blood-brain barrier, as its presence can influence the uptake of other amino acids or related compounds.


Benserazide·HCl (Ro 4-4602) (CAS 14919-77-8) References

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  2. Dopaminergic control of adenohypophyseal growth after oestrogens: negative results with L-DOPA, RO-4-4602, alpha-methyl-DOPA, apomorphine, haloperidol, pyridoxine and cyproheptadine.  |  Schreiber, V., et al. 1978. Physiol Bohemoslov. 27: 308-12. PMID: 151287
  3. The actions of dihydroxyphenylalanine and dihydroxyphenylserine on the sleep-wakefulness cycle of the rat after peripheral decarboxylase inhibition.  |  Altier, H., et al. 1975. Br J Pharmacol. 54: 101-6. PMID: 166716
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  5. Streptozotocin-induced diabetes reduces brain serotonin synthesis in rats.  |  Trulson, ME., et al. 1986. J Neurochem. 46: 1068-72. PMID: 2419504
  6. Inhibition of brain dopa-decarboxylase by RO 4-4602 infused ICV blocks alcohol drinking induced in rats by cyanamide.  |  Miñano, FJ. and Myers, RD. 1989. Psychopharmacology (Berl). 98: 176-82. PMID: 2502790
  7. Interaction of tetrahydropapaveroline with inhibition of dopa-decarboxylase by Ro 4-4602 in brain: effects on alcohol drinking in the rat.  |  Miñano, FJ., et al. 1989. Alcohol. 6: 133-7. PMID: 2713086
  8. A comparison of the discriminative stimulus properties of l-5-hydroxytryptophan in the presence of either citalopram or Ro 4-4602.  |  Winter, JC. and Rabin, RA. 1988. Pharmacol Biochem Behav. 30: 613-6. PMID: 3264918
  9. Single-dose study of slow release preparation of levodopa and benserazide (Madopar HBS) in Parkinson's disease.  |  Marion, MH., et al. 1987. Adv Neurol. 45: 493-6. PMID: 3548262
  10. Differential effect of benserazide (Ro4-4602) on the concentration of indoleamines in rat pineal and hypothalamus.  |  Arendt, J., et al. 1981. Br J Pharmacol. 72: 257-62. PMID: 7214095
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  13. Reinstatement of vaginal cycles in aged female rats.  |  Linnoila, M. and Cooper, RL. 1976. J Pharmacol Exp Ther. 199: 477-82. PMID: 988180

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Benserazide·HCl (Ro 4-4602), 100 mg

sc-200723
100 mg
$26.00

Benserazide·HCl (Ro 4-4602), 1 g

sc-200723A
1 g
$85.00