Date published: 2025-9-5

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Benoxaprofen (CAS 51234-28-7)

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Alternate Names:
(RS)-Benoxaprofen
CAS Number:
51234-28-7
Molecular Weight:
301.72
Molecular Formula:
C16H12ClNO3
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Benoxaprofen, was a non-steroidal anti-inflammatory chemical. It is a monocarboxylic acid derived from propionic acid, with a substitution of a 2-(4-chlorophenyl)-1,3-benzoxazol-5-yl group at position 2. It also exhibited properties of an antipyretic, non-narcotic analgesic, protein kinase C agonist, hepatotoxic agent, antipsoriatic, and nephrotoxin.


Benoxaprofen (CAS 51234-28-7) References

  1. Molecular orbital theory applied to the study of nonsteroidal anti-inflammatory drug efficiency.  |  Zoete, V., et al. 1999. Free Radic Biol Med. 26: 1261-6. PMID: 10381198
  2. A systematic review of NSAIDs withdrawn from the market due to hepatotoxicity: lessons learned from the bromfenac experience.  |  Goldkind, L. and Laine, L. 2006. Pharmacoepidemiol Drug Saf. 15: 213-20. PMID: 16456879
  3. Bioactivation of carboxylic acid compounds by UDP-Glucuronosyltransferases to DNA-damaging intermediates: role of glycoxidation and oxidative stress in genotoxicity.  |  Sallustio, BC., et al. 2006. Chem Res Toxicol. 19: 683-91. PMID: 16696571
  4. Mechanism of DNA cleavage mediated by photoexcited non-steroidal antiinflammatory drugs.  |  Artuso, T., et al. 1991. Photochem Photobiol. 54: 205-13. PMID: 1838196
  5. Comparison of the pro-oxidative interactions of flunoxaprofen and benoxaprofen with human polymorphonuclear leucocytes in vitro.  |  Van Rensburg, AJ., et al. 1991. Agents Actions. 33: 292-9. PMID: 1950816
  6. Glucuronidation and covalent protein binding of benoxaprofen and flunoxaprofen in sandwich-cultured rat and human hepatocytes.  |  Dong, JQ. and Smith, PC. 2009. Drug Metab Dispos. 37: 2314-22. PMID: 19773537
  7. Photobinding of drugs to cells as an indicator of potential photoallergy.  |  Miranda, MA., et al. 1995. Toxicol In Vitro. 9: 499-503. PMID: 20650119
  8. Induction of the cytochrome P450 I and IV families and peroxisomal proliferation in the liver of rats treated with benoxaprofen. Possible implications in its hepatotoxicity.  |  Ayrton, AD., et al. 1991. Biochem Pharmacol. 42: 109-15. PMID: 2069584
  9. DNA strand breaks photosensitized by benoxaprofen and other non steroidal antiinflammatory agents.  |  Artuso, T., et al. 1990. Biochem Pharmacol. 39: 407-13. PMID: 2137692
  10. Effects of clofibric acid on the biliary excretion of benoxaprofen glucuronide and taurine conjugate in rats.  |  Okada, K., et al. 2011. Pharmazie. 66: 777-83. PMID: 22026160
  11. A retrospective study of the molecular toxicology of benoxaprofen.  |  Lewis, DF., et al. 1990. Toxicology. 65: 33-47. PMID: 2274968
  12. Photochemical and photophysical properties of piroxicam and benoxaprofen in various solvents.  |  Becker, RS., et al. 1990. Photochem Photobiol. 51: 151-4. PMID: 2333332
  13. Computational Studies of the Photodegradation Mechanism of the Highly Phototoxic Agent Benoxaprofen.  |  Musa, KAK. and Eriksson, LA. 2022. ACS Omega. 7: 29475-29482. PMID: 36033698
  14. Covalent binding of acidic drugs via reactive intermediates: detection of benoxaprofen and flunoxaprofen protein adducts in biological material.  |  Dahms, M. and Spahn-Langguth, H. 1996. Pharmazie. 51: 874-81. PMID: 8985978
  15. Stereoselective metabolism of benoxaprofen in rats. Biliary excretion of benoxaprofen taurine conjugate and glucuronide.  |  Mohri, K., et al. 1998. Drug Metab Dispos. 26: 332-7. PMID: 9531520

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Benoxaprofen, 1 mg

sc-503308
1 mg
$350.00

Benoxaprofen, 10 mg

sc-503308A
10 mg
$867.00

Benoxaprofen, 100 mg

sc-503308B
100 mg
$6630.00

Benoxaprofen, 250 mg

sc-503308C
250 mg
$11750.00

Benoxaprofen, 500 mg

sc-503308D
500 mg
$21415.00

Benoxaprofen, 1 g

sc-503308E
1 g
$40300.00