Date published: 2025-10-2

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Benfotiamine (CAS 22457-89-2)

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Alternate Names:
Betivina; Biotamin; Neurostop; Nitanevril; Tabiomyl; Vitanevril; Berdi; S-Benzoylthiamine O-monophosphate
Application:
Benfotiamine is a lipid-soluble thiamine derivative
CAS Number:
22457-89-2
Purity:
≥98%
Molecular Weight:
466.45
Molecular Formula:
C19H23N4O6PS
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Benfotiamine is a synthetic chemical that is frequently employed in biochemical research due to its influence on thiamine-related pathways. It is used in studies investigating the enzymatic activity of thiamine diphosphate-dependent enzymes, which play a significant role in carbohydrate metabolism. In research applications, Benfotiamine is also utilized to explore its impact on cellular glucose metabolism, as it is involved in the activation of transketolase, an enzyme that can influence the pentose phosphate pathway. Furthermore, Benfotiamine is a subject of interest in the study of its role in oxidative stress mechanisms. The compound is also instrumental in the study of advanced glycation end-products (AGEs) and their formation, which has implications for understanding the aging process and the management of cellular health in research applications.


Benfotiamine (CAS 22457-89-2) References

  1. Benfotiamine counteracts glucose toxicity effects on endothelial progenitor cell differentiation via Akt/FoxO signaling.  |  Marchetti, V., et al. 2006. Diabetes. 55: 2231-7. PMID: 16873685
  2. Benfotiamine. Monograph.  |  . 2006. Altern Med Rev. 11: 238-42. PMID: 17217325
  3. The multifaceted therapeutic potential of benfotiamine.  |  Balakumar, P., et al. 2010. Pharmacol Res. 61: 482-8. PMID: 20188835
  4. Benfotiamine attenuates inflammatory response in LPS stimulated BV-2 microglia.  |  Bozic, I., et al. 2015. PLoS One. 10: e0118372. PMID: 25695433
  5. Benfotiamine upregulates antioxidative system in activated BV-2 microglia cells.  |  Bozic, I., et al. 2015. Front Cell Neurosci. 9: 351. PMID: 26388737
  6. Therapeutic potential of benfotiamine and its molecular targets.  |  Raj, V., et al. 2018. Eur Rev Med Pharmacol Sci. 22: 3261-3273. PMID: 29863274
  7. Benfotiamine Reduces Dendritic Cell Inflammatory Potency.  |  Djedovic, N., et al. 2021. Endocr Metab Immune Disord Drug Targets. 21: 1344-1351. PMID: 32888286
  8. Current concepts in the management of diabetic polyneuropathy.  |  Ziegler, D., et al. 2021. J Diabetes Investig. 12: 464-475. PMID: 32918837
  9. Protective effect of benfotiamine on methotrexate induced gastric damage in rats.  |  Koc, S., et al. 2021. Biotech Histochem. 96: 586-593. PMID: 33325753
  10. Neuroprotective Effects of Thiamine and Precursors with Higher Bioavailability: Focus on Benfotiamine and Dibenzoylthiamine.  |  Sambon, M., et al. 2021. Int J Mol Sci. 22: PMID: 34063830
  11. Screening, diagnosis and management of diabetic sensorimotor polyneuropathy in clinical practice: International expert consensus recommendations.  |  Ziegler, D., et al. 2022. Diabetes Res Clin Pract. 186: 109063. PMID: 34547367
  12. Therapeutic potential of vitamin B1 derivative benfotiamine from diabetes to COVID-19.  |  Allowitz, KV., et al. 2022. Future Med Chem. 14: 809-826. PMID: 35535731
  13. Pharmacokinetics of thiamine derivatives especially of benfotiamine.  |  Loew, D. 1996. Int J Clin Pharmacol Ther. 34: 47-50. PMID: 8929745

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Benfotiamine, 250 mg

sc-204639
250 mg
$51.00

Benfotiamine, 1 g

sc-204639A
1 g
$168.00