Molecular structure of Bendamustine Hydrochloride, CAS Number: 3543-75-7
Bendamustine Hydrochloride (CAS 3543-75-7)
Alternate Names:
5-[Bis(2-chloroethyl)-amino]-1-methyl-1H-benzimidazole-2-butanoic Acid Hydrochloride;Ribomustin HCl; Treanda HCl; SDX-105 HCl; 1H-Benzimidazole-2-butanoic acid; 5-[bis(2-chloroethyl)amino]-1-methyl monohydrochloride
Application:
Bendamustine Hydrochloride is a nitrogen mustard purine analog alkylator
CAS Number:
3543-75-7
Molecular Weight:
394.72
Molecular Formula:
C16H21Cl2N3O2•HCl
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Bendamustine Hydrochloride is a small molecule bifunctional DNA alkylating agent, combining a nitrogen mustard functionality with a purine-analog structure. The dense DNA-damaging functionality of bendamustine differentiates it from other compounds used as antiproliferative agents, and these functionalities are thought to promote cell death through a variety of different pathways including apoptosis and mitotic catastrophe. As a result of this, it has been examined in relation to proliferations and malignancies refractory to the effects of other DNA alkylators. In addition, bendamustine is often included in studies regarding chronic lymphocytic leukemia.
Bendamustine Hydrochloride (CAS 3543-75-7) References
- Bendamustine. | Balfour, JA. and Goa, KL. 2001. Drugs. 61: 631-8; discussion 639-40. PMID: 11368287
- In vitro evaluation of bendamustine induced apoptosis in B-chronic lymphocytic leukemia. | Schwänen, C., et al. 2002. Leukemia. 16: 2096-105. PMID: 12357363
- Advances in chemotherapy for chronic lymphocytic leukemia. | Wendtner, CM., et al. 2004. Semin Hematol. 41: 224-33. PMID: 15269882
- Bendamustine. | Keating, MJ., et al. 2008. Nat Rev Drug Discov. 7: 473-4. PMID: 18511926
- HPLC study on the stability of bendamustine hydrochloride immobilized onto polyphosphoesters. | Pencheva, I., et al. 2008. J Pharm Biomed Anal. 48: 1143-50. PMID: 18926656
- Identification and quantitation of the N-acetyl-L-cysteine S-conjugates of bendamustine and its sulfoxides in human bile after administration of bendamustine hydrochloride. | Teichert, J., et al. 2009. Drug Metab Dispos. 37: 292-301. PMID: 18971319
- Feasibility and pharmacokinetic study of bendamustine hydrochloride in combination with rituximab in relapsed or refractory aggressive B cell non-Hodgkin's lymphoma. | Ogura, M., et al. 2011. Cancer Sci. 102: 1687-92. PMID: 21624007
- Novel Validated RP-HPLC Method for Bendamustine Hydrochloride Based on Ion-pair Chromatography: Application in Determining Infusion Stability and Pharmacokinetics. | Singh, Y., et al. 2017. J Chromatogr Sci. 55: 30-39. PMID: 27993861
- Assessment of bendamustine-induced genotoxicity in eukaryotic cells. | Pereira, TS., et al. 2019. Drug Chem Toxicol. 42: 394-402. PMID: 29681187
- t-Butanol Enables Dual Functionality of Mannitol: A Cryoprotectant in Frozen Systems and Bulking Agent in Freeze-Dried Formulations. | Sonje, J., et al. 2020. Mol Pharm. 17: 3075-3086. PMID: 32633520
- Polymorphic forms of bendamustine hydrochloride: crystal structure, thermal properties and stability at ambient conditions. | Gaztañaga, P., et al. 2019. Acta Crystallogr B Struct Sci Cryst Eng Mater. 75: 933-941. PMID: 32830673
- Bendamustine hydrochloride activity against doxorubicin-resistant human breast carcinoma cell lines. | Strumberg, D., et al. 1996. Anticancer Drugs. 7: 415-21. PMID: 8826610
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Bendamustine Hydrochloride, 10 mg | sc-207320 | 10 mg | $157.00 | |||
Bendamustine Hydrochloride, 100 mg | sc-207320A | 100 mg | $474.00 |